Cordycepin is an analogue of adenosine lacking the 3'-OH. When incorporated into a growing RNA molecule, cordycepin prevents further elongation, thus producing a prematurely terminated RNA molecule. When HeLa cells are exposed to low concentrations of cordycepin, DNA and protein synthesis are unaffected during short exposure periods. The synthesis of completed ribosomal and ribosomal-precursor (45S) RNA is significantly depressed. Partially completed 45S ribosomal precursor molecules accumulate in the nucleolus. 18S ribosomal RNA can be cleaved from these incomplete precursors, while 32S ribosomal precursor cannot be produced from partially snythesized 45S molecules. The synthesis of transfer RNA is also reduced in the presence of cordycepin. The synthesis of the nuclear heterogeneous RNA species is unaffected by the drug while the cytoplasmic heterogeneous RNA is slightly reduced.
Inhibition of the synthesis of 5-phosphoribosyl-1-pyrophosphate by 3'-deoxy-adenosine and structurally related nucleoside analogs
Base composition of ribosomal RNA precursors in the HeLa cell nucleolus: further evidence of non-conservative processing
The regulation of RNA synthesis and processing in the nucleolus during inhibition of protein synthesis
THE INHIBITION OF 5-PHOSPHORIBOSYL-1-PYROPHOSPHATE FORMATION BY CORDYCEPIN TRIPHOSPHATE IN EXTRACTS OF EHRLICH ASCITES TUMOR CELLS
THE INHIBITION OF PHOSPHORIBOSYL-PYROPHOSPHATE AMIDOTRANSFERASE ACTIVITY BY CORDYCEPIN MONOPHOSPHATE
EFFECT OF 3'-DEOXYATP (CORDYCEPIN TRIPHOSPHATE) AND 2'-DEOXYATP ON THE DNA-DEPENDENT RNA NEUCLEOTIDYLTRANSFERASE FROM EHRLICH ASCITES TUMOR CELLS
Effect of cordycepin (3'-desoxyadenosine) on polytene chromosomes of Chironomus pallidivittatus salivary glands
Studies of the UV-sensitivity of virus-specific RNA synthesis in cells infected or transformed by adenovirus 5 and SV 40
Effects of 3'deoxyadenosine and actinomycin D on RNA synthesis in toad bladder: analysis of response to aldosterone
Utilization of uridine for RNA synthesis in the insect cell line CP-1268 derived from the codling moth, Laspeyresia pomonella
Present status of chemotherapy and chemoprophylaxis of animal trypanosomiasis in the Eastern hemisphere
Estrogen induction of sexual behavior in female rats and synthesis of polyadenylated messenger RNA in the ventromedial nucleus of the hypothalamus
Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis
Evidence for the existence of several molecular species in the "45S fraction" of mammalian ribosomal precursor RNA
Differential metabolism of large and small poly(A) sequences in the heterogeneous nuclear RNA of HeLa cells
RNA synthesis in HeLa cells. Pattern in hypertonic medium and its similarity to synthesis during G2-prophase
Nucleolar necklaces in chick embryo fibroblast cells. II. Microscope observations of the effect of adenosine analogues on nucleolar necklace formation
The sensitivity of RNA polymerases I and II from Novikoff hepatoma (N1S1) cells to 3'-deoxyadenosine 5'-triphosphate
Integrity of the DNA template, a prerequisite for the faithful transcription of Xenopus rDNA in vitro
Template specificities of Xenopus laevis RNA polymerases. Selective transcription of ribosomal cistrons by RNA polymerase A
The arrangement of 18-S and 28-S ribosomal ribonucleic acids within the 40-S precursor molecule of Xenopus laevis
In vitro antimalarial activity of nucleic acid precursor analogues in the simian malaria Plasmodium knowlesi
Ultrastructural observations on the inhibition of nucleolar reorganization by 3'-deoxyadenosine in Allium cepa roots
Inhibition of protein kinase activity from Trypanosoma cruzi and Trypanosoma gambiense by 3'-deoxyadenosine
Preferential in vivo inhibition of ribosomal ribonucleic acid synthesis in mouse liver by the exotoxin of Bacillus thüringiensis
The effects of inhibitors of RNA and DNA synthesis on protein synthesis and polysome levels in mouse L-cells
The effects of metabolic inhibitors on the synthesis of inducible tyrosine aminotransferase in cultured hepatoma cells
Mouse embryo development in vitro: effects of inhibitors of RNA and protein synthesis on blastocyst and post-blastocyst embryos
Effects of polyadenylation inhibition on meiosis progression in relation to the polyadenylation status of cyclins A2 and B1 during in vitro maturation of bovine oocytes
Acquisition of transcriptional competence in the 1-cell mouse embryo: requirement for recruitment of maternal mRNAs
Alteration of ribosomal precursor RNA in Novikoff hepatoma cells by 5-azacytidine. Studies on methylation of 45S and 32S RNA
Effects of 3'deoxyadenosine (cordycepin) and 2'deoxyadenosine on nucleoside transport, macromolecular synthesis, and replication of cultured Novikoff hepatoma cells
The effects of actinomycin D and cordycepin on neurite formation and acetylcholinesterase activity in mouse neuroblastoma cells
Unusual perinucleolar accumulation of ribonucleoprotein granules induced by camptothecin in isolated liver cells
Ecdysone induction of puffing in polytene chromosomes of Drosophila melanogaster. Effects of inhibitors of RNA synthesis
Effects of cordycepin on macromolecular synthesis and development in the preimplantation mouse embryo
Cordycepin rapidly collapses the intermediate filament networks into juxtanuclear caps in fibroblasts and epidermal cells
The effects of 2'-deoxycoformycin on the action of cordycepin on nuclear RNA synthesis in regenerating liver
Preferential inhibition of the synthesis of 45S ribosomal rna precursor by N-acetoxyacetylaminofluorene in rat liver epithelial cultures
Dose finding of 3'deoxyadenosine and deoxycoformycin for the treatment of Trypanosoma evansi infection: An effective and nontoxic dose
Keratinization of mouse teratoma cell line XB produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin: an in vitro model of toxicity
Differential inhibition of the in vivo synthesis of adenovirus type 5-specific ribonucleic acids by cordycepin
Cordycepin disrupts the microtubule networks and arrests Nil 8 hamster fibroblasts at the onset of mitosis
Endocrine regulation of spermatogenesis in Nereis diversicolor (annelida polychaeta): experimental study of the control of meiotic differentiation
The topographical order of 18 S and 20 S ribosomal ribonucleic acids within the 45 S precursor molecule
Inhibition of ribosomal ribonucleic acid maturation by 5-azacytidine and 8-azaguanine in Novikoff hepatoma cells
Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Effects of various metabolic inhibitors on the enzyme activity in hepatoma cells
Cordyceptin induces apoptosis through repressing hTERT expression and inducing extranuclear export of hTERT
Transcriptome analysis of the Ophiocordyceps sinensis fruiting body reveals putative genes involved in fruiting body development and cordycepin biosynthesis
HYPER RECOMBINATION1 of the THO/TREX complex plays a role in controlling transcription of the REVERSION-TO-ETHYLENE SENSITIVITY1 gene in Arabidopsis
Evidence that naturopathic therapy including Cordyceps sinensis prolongs survival of patients with hepatocellular carcinoma
Posttranscriptional regulation of cyclin A1 and cyclin A2 during mouse oocyte meiotic maturation and preimplantation development
Alterations in the maturation and structure of ribosomal precursor RNA in Novikoff hepatoma cells induced by 5-fluorocytidine
Direct and Indirect Effects on Viral Translation and RNA Replication Are Required for AUF1 Restriction of Enterovirus Infections in Human Cells
Specific inhibition of chromatin-associated poly(A) synthesis in vitro by cordycepin 5'-triphosphate
Cordycepin Downregulates Cdk-2 to Interfere with Cell Cycle and Increases Apoptosis by Generating ROS in Cervical Cancer Cells: in vitro and in silico Study
Multiplication of influenza virus in the presence of cordycepin, an inhibitor of cellular RNA synthesis
Changes in the surface of virus-induced cells recognized by cytotoxic T cells. I. Minimal requirements for lysis of ectromelia-infected P-815 cells
Effect of Cordyceps militaris Hot Water Extract on Immunomodulation-associated Gene Expression in Broilers, Gallus gallus
Relative responses of an X-ray-resistant hybrid cell-line and its parent line to X-irradiation, ultraviolet light, actinomycin D and cordycepin
Labeling of cytoplasmic liver RNA by (6- 14 C)orotic and 5-fluoro(2- 14 C)orotic acids. Effect of several inhibitors
Separation of cordycepin from Cordyceps militaris fermentation supernatant using preparative HPLC and evaluation of its antibacterial activity as an NAD(+)-dependent DNA ligase inhibitor
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