The selective potentiation of noradrenaline-induced tone by Bay K 8644 in the rabbit basilar artery.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
I LaherJ A Bevan

Abstract

A number of studies indicate that relative to the maximal tone possible, for example, to histamine, noradrenaline produces only weak contractile responses in the rabbit basilar artery. Various factors, including a limited number of alpha-adrenoceptors, have been proposed to account for the reduced response to noradrenaline. We examined the effect of the Ca2+-channel activator, Bay K 8644 (0.1 and 1.0 nM) on dose-response curves to noradrenaline, histamine, calcium (Ca2+) and potassium (K+) in ring preparations of rabbit basilar artery and central ear artery. These concentrations of Bay K 8644 (0.1 and 1.0 nM) increased the magnitude of tension developed by noradrenaline (contractility) in the basilar artery, but did not alter its sensitivity (ED50) to the adrenergic vasoconstrictor. Bay K 8644 (0.1 and 1.0 nM) did not alter the contractility or sensitivity to histamine or K+ of the rabbit basilar artery. When dose-response curves to Ca2+ were made in K+-depolarized rabbit basilar artery rings, Bay K 8644 (0.1 and 1.0 nM) dose-dependently augmented tone generated by readmission of Ca2+. Bay K 8644 (0.1 and 1.0 nM) did not alter responses to noradrenaline, histamine, or K+ in rabbit central ear artery preparations. These results ...Continue Reading

References

Jul 1, 1976·Circulation Research·T J LeeJ A Bevan
Sep 1, 1985·Biochemical Pharmacology·M SalaicesJ Reviriego
Oct 22, 1985·European Journal of Pharmacology·K S Hwang, C Van Breemen
May 1, 1987·Journal of Molecular and Cellular Cardiology·M Bechem, M Schramm
Jan 1, 1985·Acta Physiologica Scandinavica·T K Uski, K E Andersson
Nov 1, 1984·Canadian Journal of Physiology and Pharmacology·C M SuD J Triggle
Sep 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E Müller-Schweinitzer, P Neumann
Jun 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J McCulloch, L Edvinsson
Jan 1, 1984·Reviews of Physiology, Biochemistry and Pharmacology·D W Busija, D D Heistad
Dec 1, 1981·Journal of Autonomic Pharmacology·T A McCalden

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Citations

Jan 1, 1995·Pharmacology & Therapeutics·E AlborchG Torregrosa
Dec 1, 1991·Stroke; a Journal of Cerebral Circulation·P GermannJ A Bevan

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