The selectivity of regenerating motor and sensory axons

Journal of Reconstructive Microsurgery
Y MakiH Narisawa

Abstract

Functional results of peripheral nerve repair have been hampered by misdirection of regenerating axons. The purpose of this study was to determine in a rat femoral nerve model whether regenerating motor and sensory axons from a proximal nerve stump select the appropriate distal motor or sensory branch. In two experiments, the proximal stump of the motor or sensory branches was sutured to the distal motor sensory stumps, so that the three branches were parallel and the three transected ends faced in the same direction. More regenerated axons from both the proximal motor and sensory stumps entered the distal sensory stump. The number of misdirected axons did not decrease over time. The selective regeneration of motor axons toward the distal motor stump could not be validated. In this study, neurotropism appeared to play a measurable role in sensory axon regeneration, but not in motor axon regeneration. Pruning of the misdirected axons was not demonstrated.

Citations

Apr 6, 2005·Hand Surgery : an International Journal Devoted to Hand and Upper Limb Surgery and Related Research : Journal of the Asia-Pacific Federation of Societies for Surgery of the Hand·Masahiro KoizumiNaoto Tsubokawa
Nov 16, 2004·Journal of Neurosurgery·Jayme Augusto Bertelli, Marcos Flávio Ghizoni
Oct 26, 2005·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Yutaka MakiNaoto Tsubokawa
Aug 18, 1999·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Y TakahashiT Tajima
Aug 18, 1999·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Y IwabuchiH Narisawa
Oct 2, 2002·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Yutaka Maki
Apr 8, 2003·Journal of the Peripheral Nervous System : JPNS·Carlo A J HoltzerRalph T W M Thomeer
Aug 6, 2016·Journal of Neurosurgery. Spine·Jayme A Bertelli, Marcos F Ghizoni
Jan 26, 2007·Acta Physiologica·G Lundborg, B Rosén
Dec 30, 1999·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·N TsubokawaH Narisawa

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