PMID: 2494285Mar 1, 1989Paper

The self-priming action of LHRH increases the low pituitary LH and FSH response caused by ovarian factors: observations in vitro

The Journal of Endocrinology
J de KoningG P van Rees

Abstract

Pituitary glands taken from intact rats on day 2 of dioestrus and incubated with LHRH show a biphasic pattern of LH and FSH release. Initially the release of the gonadotrophins is low (first-phase or lag-phase response), but increases during further incubation with LHRH (second-phase or primed-state response). Removal of the influence of an unidentified ovarian factor either by ovariectomy or prolonged incubation in medium only leads to an increased (lag-phase) response to LHRH. The development of the increased response after prolonged incubation was prevented by the addition of cycloheximide to the media, implicating that this process is dependent upon the synthesis of protein. Steroid-free material (bovine follicular fluid or rat ovarian extracts) prevented the development of this process. In addition, it was shown that steroid-free rat ovarian extracts were also able to induce the development of a lag phase in pituitary glands from ovariectomized rats. Finally, it was found that steroid-free ovarian extracts reversed the self-priming effect of LHRH. The biological activity which reduced the responsiveness of the pituitary gland towards stimulation by LHRH was eliminated after the use of protein-denaturating techniques such a...Continue Reading

Citations

Mar 1, 1994·Neuroscience and Behavioral Physiology·V N BabichevE I Adamskaya
Jan 12, 1991·Lancet·J de KoningD W Koppenaal
Nov 1, 1991·Clinical Endocrinology·A H Balen, H S Jacobs

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