The semantic variant of primary progressive aphasia: clinical and neuroimaging evidence in single subjects

PloS One
Leonardo IaccarinoD Perani

Abstract

We present a clinical-neuroimaging study in a series of patients with a clinical diagnosis of semantic variant of primary progressive aphasia (svPPA), with the aim to provide clinical-functional correlations of the cognitive and behavioral manifestations at the single-subject level. We performed neuropsychological investigations, 18F-FDG-PET single-subject and group analysis, with an optimized SPM voxel-based approach, and correlation analyses. A measurement of white matter integrity by means of diffusion tensor imaging (DTI) was also available for a subgroup of patients. Cognitive assessment confirmed the presence of typical semantic memory deficits in all patients, with a relative sparing of executive, attentional, visuo-constructional, and episodic memory domains. 18F-FDG-PET showed a consistent pattern of cerebral hypometabolism across all patients, which correlated with performance in semantic memory tasks. In addition, a majority of patients also presented with behavioral disturbances associated with metabolic dysfunction in limbic structures. In a subgroup of cases the DTI analysis showed FA abnormalities in the inferior longitudinal and uncinate fasciculi. Each svPPA individual had functional derangement involving an ex...Continue Reading

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Citations

Sep 1, 2015·Neuropsychology Review·Shailendra SegobinFrancis Eustache
Mar 14, 2017·Alzheimer Disease and Associated Disorders·Borna BonakdarpourRobert S Hurley
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Oct 13, 2020·American Journal of Alzheimer's Disease and Other Dementias·Brendan Stuart Hackett Weekes
Apr 12, 2021·CNS Drugs·Rita KhouryGeorge T Grossberg

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Software Mentioned

MATLAB
BrainNet Viewer
SPM
fslmeants
WFUPickAtlas )
bedpostX
MarsBar
SPM5
FMRIB Software Library
probtrackX

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