PMID: 6987354Mar 1, 1980Paper

The sensitivity and specificity of an agglutination test for antibodies to streptococcal extracellular antigens: a quantitative analysis and comparison of the Streptozyme test with the anti-streptolysin O and anti-deoxyribonuclease B tests

The Journal of Pediatrics
E L Kaplan, B B Huew

Abstract

As a part of studies of streptococcal infections of the upper respiratory tract, sera from 142 individuals (mean age 11.9 years) with signs and symptoms on tonsillitis or pharyngitis and their family contacts were studied to quantitatively evaluate the sensitivity and specificity of the Streptozyme test. We also compared this agglutination test for streptococcal extracellular antibodies with the antistreptolysin O and antideoxyribonuclease B tests. Using different lots of Streptozyme reagent we found evidence suggesting variation in the strength of the reagent from lot to lot. Evaluation of the group specificity of the Streptozyme test suggests that it may not be specific for antibodies to extracellular products of group A streptococci, since a response to this test was seen in individuals with only non-group A strains isolated from their upper respiratory tracts. In patients with group A streptococci isolated from the upper respiratory tract, the quantitative sensitivity of the antibody response as measured by the Streptozyme test is comparable to, but no greater than, the ASO or anti-DNase B tests. Our analysis of upper limits of normal for the Streptozyme test in the study population indicates that previous recommendations f...Continue Reading

Citations

Nov 1, 1990·Annals of Emergency Medicine·U E Gallo, P B Fontanarosa
Apr 9, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C L Phillips, S P Andreoli
May 18, 2006·Acta Ophthalmologica Scandinavica·Micheal J GallagherMike Gavin
Jan 7, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T ParksA C Steer
Oct 14, 2014·Frontiers in Cellular and Infection Microbiology·Juan Cristobal Jimenez, Michael J Federle
Mar 2, 2018·Journal of Clinical Microbiology·Takahiro YamaguchiKentaro Kawatsu

Related Concepts

Streptozyme
Teens
Agglutination Tests
Antibodies, Bacterial
Antistreptolysin O
Alkaline DNase
Erythrocytes
Hydrolase
Indicators
Upper Respiratory Infections

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