The sensitivity and specificity of platelet autoantibody testing in immune thrombocytopenia: a systematic review and meta-analysis of a diagnostic test

Journal of Thrombosis and Haemostasis : JTH
John R VrbenskyIshac Nazy

Abstract

Essentials The diagnosis of ITP is based on a platelet count < 100 × 109  L-1 and exclusion of other causes. There are no standard tests or biomarkers to diagnose ITP. The sensitivity of platelet autoantibody testing is low (53%). The specificity is high (> 90%). A positive autoantibody test can be useful to rule in ITP but a negative does not rule out ITP. SUMMARY: Background Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count and an increased risk of bleeding. The sensitivity and specificity of platelet autoantibody tests is variable and their utility is uncertain. Objective The purpose of this study was to perform a systematic review and meta-analysis of platelet autoantibody tests in the diagnosis of ITP. Methods Ovid Medline, PubMed, and Web of Science were searched from inception until 31 May 2018. Two reviewers independently assessed studies for eligibility and extracted data. Studies that reported testing results for antiplatelet autoantibodies on platelets (direct tests) or in plasma/serum (indirect tests) for 20 or more ITP patients were included. Results Pooled estimates for sensitivity and specificity were calculated using a random effects model. Pooled estimates for the sen...Continue Reading

References

Mar 29, 2002·American Journal of Hematology·Bradley C Gehrs, Richard C Friedberg
Aug 26, 2006·Pediatric Blood & Cancer·Simon PanzerIngrid Pabinger
Jul 28, 2007·European Journal of Haematology·Simon PanzerIngrid Pabinger
Feb 18, 2011·Blood·Cindy NeunertUNKNOWN American Society of Hematology
Feb 16, 2012·Journal of Thrombosis and Haemostasis : JTH·D M ArnoldUNKNOWN Platelet Immunology Scientific Subcommittee of the ISTH
Oct 30, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yang HeChang-geng Ruan
Oct 1, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yunxiao ZhaoYang He
May 3, 2016·American Journal of Hematology·Mary SalibDonald M Arnold
Apr 27, 2017·British Journal of Haematology·Donald M ArnoldIshac Nazy
Mar 14, 2018·British Journal of Haematology·Ishac NazyDonald M Arnold
May 29, 2018·British Journal of Haematology·Leendert PorcelijnMasja de Haas
Dec 7, 2018·Hematology·John G KeltonDonald M Arnold

❮ Previous
Next ❯

Citations

Dec 19, 2019·British Journal of Haematology·John R VrbenskyIshac Nazy
Jul 1, 2020·Blood Advances·Sabrina ShresthaDonald M Arnold
Mar 12, 2020·Blood·Yosuke MorodomiTaisuke Kanaji
Nov 4, 2020·Clinical Science·Sarah M HicksElizabeth E Gardiner
Jul 28, 2020·La Revue de médecine interne·M EbboB Godeau
Feb 24, 2021·The American Journal of Medicine·Vasilios KalasAnand A Patel
Apr 12, 2021·Pathology·Shiying Silvia ZhengBeng Hock Chong
May 2, 2021·Scientific Reports·Anastasia A IgnatovaMikhail A Panteleev
Jul 28, 2021·Expert Opinion on Biological Therapy·Frederick ChenAdrian Newland
Aug 8, 2021·Journal of Clinical Medicine·Anne-Tess C JolinkRick Kapur
Sep 5, 2021·BMJ Case Reports·Joanna CachiaDavid Pace
Sep 7, 2021·European Journal of Haematology·John R VrbenskyDonald M Arnold
Oct 13, 2021·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maria L Lozano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.