The sensitivity of laboratory tests assessing driving related skills to dose-related impairment of alcohol: A literature review

Accident; Analysis and Prevention
Stefan JongenA Vermeeren

Abstract

Laboratory tests assessing driving related skills can be useful as initial screening tools to assess potential drug induced impairment as part of a standardized behavioural assessment. Unfortunately, consensus about which laboratory tests should be included to reliably assess drug induced impairment has not yet been reached. The aim of the present review was to evaluate the sensitivity of laboratory tests to the dose dependent effects of alcohol, as a benchmark, on performance parameters. In total, 179 experimental studies were included. Results show that a cued go/no-go task and a divided attention test with primary tracking and secondary visual search were consistently sensitive to the impairing effects at medium and high blood alcohol concentrations. Driving performance assessed in a simulator was less sensitive to the effects of alcohol as compared to naturalistic, on-the-road driving. In conclusion, replicating results of several potentially useful tests and their predictive validity of actual driving impairment should deserve further research. In addition, driving simulators should be validated and compared head to head to naturalistic driving in order to increase construct validity.

References

Jan 1, 1990·Annual Review of Neuroscience·M I Posner, S E Petersen
Dec 1, 1985·Physiology & Behavior·W E Gibson
Jan 1, 1984·British Journal of Clinical Pharmacology·A N GriffithsA Richens
Jan 1, 1984·British Journal of Clinical Pharmacology·J F O'Hanlon
Mar 1, 1995·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·H W Robbe, J F O'Hanlon
Apr 1, 1995·Psychopharmacology·H S Koelega
May 11, 1999·Alcoholism, Clinical and Experimental Research·L Holdstock, H de Wit
Jun 17, 1999·Alcoholism, Clinical and Experimental Research·A LiguoriJ H Robinson
Sep 2, 1999·Alcoholism, Clinical and Experimental Research·D M DoughertyJ M Bjork
Jan 8, 2000·Journal of Studies on Alcohol·K MarinkovicI Maltzman
Mar 25, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M E McCaulL J Cheskin
Apr 11, 2000·Journal of Studies on Alcohol·M T Fillmore, M Vogel-Sprott
Aug 6, 2000·Journal of Studies on Alcohol·M T FillmoreT A Schweizer
Oct 26, 2000·European Journal of Clinical Pharmacology·J VanakoskiT Seppälä
Dec 5, 2000·British Journal of Anaesthesia·S A GrantG N Kenny
Feb 24, 2001·Journal of Studies on Alcohol·M T FillmoreT A Schweizer
Mar 10, 2001·Alcoholism, Clinical and Experimental Research·K E Grattan, M Vogel-Sprott
Apr 9, 2001·Psychopharmacology·T SchulteB A Sabel
May 1, 2001·Alcoholism, Clinical and Experimental Research·L Holdstock, H de Wit
May 30, 2001·Drug and Alcohol Dependence·A Liguori, J H Robinson
Jul 13, 2001·Journal of Psychopharmacology·E CameronB Tiplady
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·Cándido Hernández-LópezRafael de La Torre
Jan 18, 2002·Psychopharmacology·M Z Mintzer, R R Griffiths
Apr 13, 2002·Journal of Psychopharmacology·Annemiek VermeerenJames F O'Hanlon
Apr 20, 2002·Alcoholism, Clinical and Experimental Research·T BlekherT-K Li
Apr 24, 2002·Journal of Cognitive Neuroscience·Jin FanMichael I Posner
May 16, 2002·Clinical & Experimental Ophthalmology·Suzane Vassallo, Larry A Abel
Jun 18, 2002·Alcoholism, Clinical and Experimental Research·Andrea C KingAlyson Schuster
Aug 6, 2002·Journal of Studies on Alcohol·Jennifer N Fogarty, Muriel Vogel-Sprott
Oct 31, 2002·Human Psychopharmacology·C. T. J. Lamers, J. G. Ramaekers
Oct 31, 2002·Human Psychopharmacology·J. G. RamaekersJ. F. O'Hanlon
Oct 31, 2002·Human Psychopharmacology·Scott E BurianJohn H Robinson
Oct 31, 2002·Human Psychopharmacology·Michelle MackayAndrew B Scholey
Dec 31, 2002·Journal of Psychopharmacology·K FarquharP Wright
Jan 17, 2003·Journal of Studies on Alcohol·Mark T FillmoreJulietta T Rice

❮ Previous
Next ❯

Citations

Mar 10, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Michael G Holland, Robin E Ferner
Dec 6, 2018·British Journal of Clinical Pharmacology·Maren Cecilie StrandJohannes G Ramaekers
Jul 21, 2017·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Brian SuffolettoTammy Chung
Mar 7, 2021·Accident; Analysis and Prevention·Harriet GarrissonSarah Benson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.