The sensitivity to noxious heat in relation to brain and liver opioid glucuronidation in inbred strains of mice

Pain
A WahlströmAnders Rane

Abstract

The glucuronidation of morphine and naloxone was demonstrated in the brain and liver in 2 inbred strains of mice, C57BL/6J (B6) and DBA/2J (D2) and their F1 hybrid generation. These strains showed a significant difference in latency of withdrawal in the tail-immersion test, the B6 strain being the most sensitive. The rate of naloxone glucuronidation in the brain was 5 times higher in the B6 than in the D2 strain. In the liver the UDP-glucuronosyl transferase (UDPGT) activity was slightly higher in the D2 strain. The naloxone- and morphine-3'-glucuronide (N3G, M3G) formation rate ratio was close to 1 in both the brain and liver in all except the B6 strain, where it was 2.6 in the brain. There was a correlation between formation rate of M3G and N3G (r = 0.65 brain and r = 0.73 liver). Our results indicate a common glucuronidation pathway for morphine and naloxone.

References

Oct 1, 1976·Biochemical Genetics·E M Håkansson
Dec 28, 1987·Life Sciences·G W PasternakC E Inturrisi
Jan 1, 1987·Pharmacology & Toxicology·C B Christensen, L N Jørgensen
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Nov 1, 1988·Pain·Agneta WahlströmAnders Rane
Apr 1, 1985·British Journal of Clinical Pharmacology·J SäweA Rane
Jan 1, 1982·European Journal of Clinical Pharmacology·G M PacificiA Rane
Dec 1, 1951·Annals of the New York Academy of Sciences·W H FISHMAN

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Citations

Jun 9, 1992·Biochemical Pharmacology·A J LawrenceD Billington
Dec 19, 2002·Free Radical Biology & Medicine·Manal M Abd El MohsenCatherine A Rice-Evans
Jan 14, 2010·Drug Metabolism Reviews·Jean-Marie HeydelAnne-Marie Le Bon

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