The sensitization of mucosal mast cells during infections with Trichostrongylus colubriformis or Haemonchus contortus in sheep

International Journal for Parasitology
T BendixsenW O Jones

Abstract

Responses of isolated mucosal mast cells (MMC) during infections with either Trichostrongylus colubriformis or Haemonchus contortus were examined by measuring the release of sheep mast cell protease (SMCP) in a degranulation assay. MMC from sheep immune to T. colubriformis released maximal amounts of SMCP and histamine within 0.5h of incubation with larval antigen whereas maximum secretion of leukotrienes occurred 3h after addition of antigen. It was only after 8 weeks of a primary T. colubriformis infection, that MMC released significantly elevated levels of SMCP (23%); this occurred when the worm burden was being rejected. In contrast, the SMCP release from MMC of immune sheep was significantly higher at 40%, and occurred within 1-4 days after challenge (DAC). The SMCP release peaked at 6-8 DAC at 51%, and declined after 56 DAC to < 25%. MMC isolated from the duodenum and mid-small intestine of immune sheep released 2-3 times higher proportion of SMCP than did cells recovered from the terminal ileum. Mast cell numbers were similar in the 3 regions but the quantity of globule leucocytes (GL) was 2.5 times higher in the duodenum. During infections with H. contortus in the abomasum, MMC isolated from the small intestine released...Continue Reading

References

Jan 1, 1992·Annals of the New York Academy of Sciences·D WeinreichJ H Leal-Cardoso
Apr 1, 1992·Veterinary Immunology and Immunopathology·J F HuntleyR Moqbel
Apr 1, 1992·International Journal for Parasitology·S J McClureW O Jones
Jul 1, 1992·International Journal for Parasitology·W O JonesD L Emery
Jun 1, 1991·International Journal for Parasitology·W O Jones, D L Emery
Jan 1, 1991·International Archives of Allergy and Applied Immunology·M K ChurchJ P Caulfield
Sep 1, 1987·Parasite Immunology·J F HuntleyH R Miller
Feb 1, 1982·The Journal of Experimental Medicine·A JörgS J Klebanoff
Oct 1, 1981·International Journal for Parasitology·D B Adams, K J Beh
Oct 1, 1993·Immunology and Cell Biology·D L EmeryB M Wagland
Dec 1, 1993·International Journal for Parasitology·E H Barnes, R J Dobson

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Citations

Nov 1, 1996·International Journal for Parasitology·D M PattersonA J Russel
Mar 26, 1998·International Journal for Parasitology·R J ShawM M McNeill
Dec 30, 1999·Veterinary Immunology and Immunopathology·A J HusbandK W Beagley
Jan 15, 2003·Clinical Microbiology Reviews·Wenbao ZhangDonald P McManus
May 28, 2009·New Zealand Veterinary Journal·S J McClure
Dec 1, 1996·Immunology and Cell Biology·M RiffkinP Wood

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