The SENSOR Study: Protocol for a Mixed-Methods Study of Self-Management Checks to Predict Exacerbations of Pseudomonas Aeruginosa in Patients with Long-Term Respiratory Conditions

JMIR Research Protocols
Claire RobertsAnoop J Chauhan

Abstract

There are an estimated three million people in the United Kingdom with chronic obstructive pulmonary disease (COPD), and the incidence of bronchiectasis is estimated at around 0.1% but is more common in COPD and severe asthma. Both COPD and bronchiectasis are characterized by exacerbations in which bacteria play a central role. Pseudomonas aeruginosa is isolated from sputum samples from 4% to 15% of adults with COPD and is more likely to be isolated from patients with severe disease. Earlier detection of exacerbations may improve morbidity and mortality by expediting treatment. Aseptika Ltd has developed a system for patients to self-monitor important physiological measurements including levels of physical activity, peak flow, forced expiratory volume (FEV1), and biomarkers for P aeruginosa in sputum. We aim to test this system in 20 participants with P aeruginosa colonization and 10 controls with Haemophilus influenzae. We plan to recruit 30 adult participants with COPD or non-CF bronchiectasis who have cultured P aeruginosa or H influenzae during an exacerbation in the last 6 months. They must produce sputum on most days and should have been stable for 4 weeks prior to entry. Daily data collected will include symptoms, health...Continue Reading

References

May 1, 1995·Qualitative Health Research·Stephen C Brock
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·David Lieberman, Devora Lieberman
Apr 27, 2005·Archives of Internal Medicine·Antoni RosellAntoni Torres
Jul 22, 2010·Thorax·M C PasteurUNKNOWN British Thoracic Society Bronchiectasis non-CF Guideline Group

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Methods Mentioned

BETA
urine collection

Software Mentioned

Activ8rlives
Aseptika
NVivo
Excel
SENSOR

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