The sentinel node biopsy in early gastric cancer: a preliminary study

Langenbeck's Archives of Surgery
Gianni MuraGiorgio M Verdecchia

Abstract

Sentinel node biopsy is currently used in surgery of malignant melanoma and breast cancer. The feasibility of sentinel node mapping in gastrointestinal cancers and its diagnostic sensitivity is unclear. It could be of particular value in the management of early gastric cancer in which radical D2 lymphadenectomy may be unnecessary. From January 2004 to June 2005, ten patients with preoperative diagnosis of early gastric cancer and no nodal involvement (cT1N0) were submitted to sentinel node biopsy using the dual mapping procedure with endoscopic blue dye and 99mTc radio colloid injection. All the patients underwent standard radical gastrectomy and D2 lymphadenectomy. The resected nodes were evaluated by routine (hematoxylin-eosin) histopathological examination; the sentinel (blue or hot) nodes, in addition, were evaluated with immunohistochemistry for cytokeratin. The detection rate of this procedure was 100%. The preliminary results and perspectives for feasibility of sentinel node biopsy and its accuracy in predicting the nodal status in early gastric cancer are discussed.

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Citations

Oct 1, 2008·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Robert Michael Kwee, Thomas Christian Kwee
Apr 25, 2009·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Robert Michael Kwee, Thomas Christian Kwee
Jun 13, 2013·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Mehmet Fatih CanSadettin Cetiner
Jan 29, 2009·World Journal of Surgical Oncology·Stephen P PovoskiEdward W Martin
Dec 18, 2013·Current Problems in Surgery·Victoria O'ConnorAnton J Bilchik
Jul 15, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F A V SantosA J A Wainstein
Jan 7, 2015·World Journal of Gastroenterology : WJG·Sang-Wook SeoJeong-Hun Lee

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