The sentinel node in cervical cancer: scintigraphy and laparoscopic gamma probe-guided biopsy

European Journal of Nuclear Medicine and Molecular Imaging
R PijpersRené H M Verheijen

Abstract

The sentinel node (SN) procedure has been proven to be a valuable technique in the staging and treatment of a number of solid tumours. We evaluated the feasibility of SN biopsy with a laparoscopic gamma probe and dye guidance in 34 patients with clinically localised cervical cancer. After peritumoural injection of 140 MBq 99mTc colloidal albumin, dynamic and late static images were obtained. Just before the laparoscopic procedure, blue dye was injected. Blue and radioactive lymph nodes were excised followed by a regular lymphadenectomy. Lymphoscintigraphy revealed 70 SNs in 50 basins during dynamic imaging and 83 SNs in 63 basins at late imaging. SNs were visualised in 97% of the patients, bilaterally in 30 and unilaterally in three. Seventy-four of the 105 radioactive lymph nodes that were excised laparoscopically were considered to be SNs, 53 being blue as well, and were sent for frozen section. Nine foci that had been seen on scintigraphy could not be found either intraoperatively or in the remaining lymphadenectomy specimen. Four blue nodes were excised in three of five basins that had shown no foci during scintigraphy. In 17 basins of 12 patients, tumour-positive lymph nodes were found. In one of them a micrometastasis was...Continue Reading

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Citations

Mar 11, 2005·European Journal of Nuclear Medicine and Molecular Imaging·D WydraT Bandurski
May 24, 2005·European Journal of Nuclear Medicine and Molecular Imaging·I RocaJ Xercavins
Jul 3, 2008·World Journal of Surgery·P G H M RaijmakersP Lips
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May 22, 2008·World Journal of Surgical Oncology·Ali AyhanPolat Dursun
Jan 29, 2009·World Journal of Surgical Oncology·Stephen P PovoskiEdward W Martin
May 17, 2007·Annals of Surgical Oncology·Charles CoutantEmmanuel Barranger
May 9, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sabas C VieiraLuiz C Zeferino
Jul 14, 2007·Gynecologic Oncology·Jonas van de LandeRené H M Verheijen
Oct 20, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Noortje H M Van OostrumRudy Van Den Broecke
Nov 13, 2015·IEEE Transactions on Medical Imaging·Bernhard FuerstNassir Navab
Jun 13, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T Adib, D P J Barton
Apr 8, 2006·Gynecologic Oncology·Simone MarnitzUNKNOWN German Association of Gynecologic Oncologists (AGO)
Apr 4, 2006·American Journal of Obstetrics and Gynecology·Michael FrumovitzCharles F Levenback
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Aug 7, 2017·The Journal of Veterinary Medical Science·Hyunjoo LimWan Hee Kim
Aug 2, 2008·The American Journal of Surgical Pathology·Elizabeth D EuscherMichael T Deavers
Dec 24, 2019·Archives of Pathology & Laboratory Medicine·Pavel DundrRadek Jakša

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