The separate and combined effects of early undernutrition and environmental complexity at different ages on cerebral measures in rats

Developmental Psychobiology
H B Katz, C A Davies

Abstract

Rats were either undernourished or fed normally during the suckling period, then at 1 and 5 months of age littermates were housed in enriched or impoverished environments for 30 days. The undernutrition caused lasting reductions in the weight and size of the cerebrum and in parameters of the hippocampus, but significant deficits were not observed in the thickness and area of the occipital cortex. Differential housing differed from early undernutrition in that its largest effects were on cortical parameters, but the effects of the two conditions did partly overlap. This meant that some nutritionally induced deficits could be modified later by manipulating environmental complexity. The cerebral response of the previously undernourished rats to differential environments was not distinguishable from that of well-fed controls on the basis of the gross anatomical changes that were measured. Furthermore, no significant differences were found between the environmental effects in young and mature rats, although the latter's response tended to be somewhat less for most parameters.

References

Jul 28, 1979·Lancet·S Grantham-McGregorW N Schofield
Jan 1, 1979·The International Journal of Neuroscience·R N Walsh, R A Cummins
Dec 19, 1975·Science·M WinickR C Harris
Jan 1, 1976·Journal of Neurobiology·M C DiamondM R Rosenzweig
Sep 1, 1966·The Journal of Comparative Neurology·M C DiamondE L Bennett
May 1, 1974·British Medical Bulletin·J Dobbing, J L Smart
Jan 1, 1973·Developmental Psychobiology·R N WalshO E Budtz-Olsen
Aug 1, 1972·Perceptual and Motor Skills·A M WellsR R Zimmermann
Jan 1, 1981·The International Journal of Neuroscience·R N Walsh
Apr 1, 1980·Experimental Neurology·J R ConnorR E Johnson
Oct 15, 1980·The Journal of Comparative Neurology·M LaiA J Patel
Feb 1, 1964·Journal of Comparative and Physiological Psychology·S SCHWARTZ

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Citations

May 10, 2005·Behavioural Brain Research·Andréa da Silva HernandesSebastião Sousa Almeida
Aug 15, 1991·The Journal of Comparative Neurology·S Diáz-CintraP J Morgane
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·P J MorganeJ R Galler
Aug 1, 1988·Early Human Development·K S Bedi, P G Bhide
Mar 1, 1997·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L F RocinholiL M De-Oliveira
Aug 21, 2018·Drinking Water Engineering and Science·Michael J DavisThomas N Taxon
Jul 1, 1990·The Proceedings of the Nutrition Society·J Dobbing
Jan 1, 1984·Nutrition Reviews·J Dobbing

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