PMID: 4881974Nov 1, 1968Paper

The sequence of amino acids in insulin isolated from islet tissue of the cod (Gadus callarias)

The Biochemical Journal
K B ReidA Youngson

Abstract

1. S-Aminoethylcysteinyl derivatives of the A and B chains of cod insulin were prepared from the individual S-sulpho chains. 2. Studies on small peptides derived from the S-aminoethylated peptide chains by treatment with trypsin allowed the amino acid sequences in the region of the cysteinyl residues of the A and B peptide chains to be defined. 3. The six amide groups in cod insulin were located by complete digestion of small peptides from the A and B chains with aminopeptidase followed by amino acid analyses. 4. The results, together with previous studies on the oxidized A and B chains, define the sequences of the 51 amino acids that constitute cod insulin.

Citations

Feb 1, 1982·European Journal of Biochemistry·A MakowerS Rosenthal
Jun 30, 1977·Nature·P T Grant, A M Mackie
Jun 1, 1989·Fish Physiology and Biochemistry·E M Plisetskaya
Jun 1, 1989·Fish Physiology and Biochemistry·A Gorbman
Aug 5, 1977·Journal of Molecular Evolution·J J Beintema
May 18, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·J A de LimaJ M Conlon
Aug 8, 1974·Biochimica Et Biophysica Acta·A LukowskyT A Rapoport
Jun 15, 1971·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R L HazelwoodH G Pollock
May 1, 1987·General and Comparative Endocrinology·J M ConlonL Thim
May 5, 1972·Science·W A FrazierR A Bradshaw

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