PMID: 2117550Aug 20, 1990Paper

The sequence of the hemoregulatory peptide is present in Gi alpha proteins

FEBS Letters
O D LaerumD Kamp

Abstract

The hemoregulatory peptide PyroGlu-Glu-Asp-Cys-Lys (HP5b), which inhibits myelopoietic colony formation in vitro, is shown to be a sequence motif which is also part of the effector domain of Gi alpha proteins. Out of 8 synthetic peptides with sequence variations of HP5b, those with the closest similarity to the Gi alpha sequence are biologically active. The inhibitory effect appears to be dependent on the blocked N-terminus. It is postulated that these peptides may interfere with signal transduction mediated by Gi alpha proteins.

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Citations

Aug 1, 1991·Trends in Pharmacological Sciences·M H Moser, W R Paukovits
Jan 1, 1990·Progress in Growth Factor Research·G J Graham, I B Pragnell
Jan 1, 1991·Annals of the New York Academy of Sciences·M GuigonA Najman
Jul 1, 1992·Baillière's Clinical Haematology·E G Wright, I B Pragnell
Oct 21, 2015·Endocrine Reviews·Alberto Roselló-Díez, Alexandra L Joyner
Dec 12, 2017·Cell Proliferation·T Rytömaa, K Grip-Rytömaa

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