PMID: 2106568Mar 1, 1990Paper

The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface

The Journal of Experimental Medicine
G WilliamsM Neuberger

Abstract

Membrane IgM is expressed on the surface of B lymphocytes. It is not transported to the surface of transfected plasmacytoma or COS cells. Here, we show that mutation of four hydrophilic amino acids in the microm transmembrane is sufficient to overcome the intracellular retention of membrane IgM in non-B cells. This suggests that the B cell-specific IgM-associated proteins that have been postulated to assist the transport of membrane IgM to the cell surface (3) act either by forming a hydrophobic sheath that surrounds the microm transmembrane segment or by displacing an interaction with this segment that would otherwise cause retention. Experiments with a CD8/mu hybrid H chain indicate that the proteins that assist the transport of membrane IgM to the B cell surface at most need the mu CH4 and transmembrane/cytoplasmic portion for interaction.

References

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Citations

Sep 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J H HankeP S Changelian
Feb 6, 2002·Springer Seminars in Immunopathology·E M Fuentes-Pananá, J G Monroe
Nov 1, 1993·Molecular Immunology·G T WilliamsM S Neuberger
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May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K S CampbellJ C Cambier
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·G T WilliamsM S Neuberger
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Jun 19, 2018·Bioscience, Biotechnology, and Biochemistry·Tatsuki KikegawaYuri Mukai
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Mar 1, 2020·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Yangyang FengWanli Liu

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