PMID: 8586821Sep 1, 1995Paper

The sera of spontaneously hypertensive rats contain agonistic auto-antibodies against the beta 1-adrenoceptor

Journal of Hypertension
G WallukatE Rohde

Abstract

To examine auto-antibodies in the sera of spontaneously hypertensive rats (SHR) and investigate the possibility of abnormalities of the immune system in those rats. Blood samples were taken from 18-month-old SHR and age-matched Wistar-Kyoto (WKY) rats. The immunoglobulin fraction was prepared from the rat sera. Immunoglobulins were investigated in a sensitive biological test system using spontaneously beating neonatal rat heart myocytes. Immunoglobulins prepared from the sera of the 18-month-old SHR increased the beating frequency of cultured rat heart myocytes. This positive chronotropic effect induced by the auto-antibody-containing immunoglobulin fraction was realized via the beta 1-adrenergic receptor. The sera of the investigated ageing SHR contain agonistic auto-antibodies directed against the beta 1-adrenoceptor. These anti-beta-adrenoceptor antibodies in the SHR, like those in the sera of cardiomyopathic patients, recognize in most cases the second extracellular loop of the beta 1-adrenoceptor as the site of the antigenic determinant, and act in a similar way to the antibodies observed in the sera of cardiomyopathic patients. The present findings provide the opportunity of using ageing SHR as a model to investigate the ...Continue Reading

Citations

Jul 23, 2014·BioMed Research International·Christopher T ChanGrant R Drummond
Jul 5, 2016·European Journal of Pharmacology·Annekathrin HaberlandGerd Wallukat
Jun 21, 2017·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyang LiHongjie Dai
Sep 10, 2015·Hypertension·Christopher T ChanGrant R Drummond
Feb 16, 2017·American Journal of Hypertension·Catalina A Lopez Gelston, Brett M Mitchell
Apr 18, 2019·Nature Reviews. Immunology·Grant R DrummondChristopher G Sobey
Jul 20, 2019·Current Hypertension Reports·Tomasz P Mikolajczyk, Tomasz J Guzik
Aug 8, 2021·British Journal of Pharmacology·Hamdi A JamaFrancine Z Marques

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