The serological investigation of red cell incompatible transfusion reactions

Anaesthesia and Intensive Care
D B Klarkowski


The hospital blood bank plays a key role in the diagnosis of acute transfusion reactions involving red cell incompatibility. This paper discusses the interpretation of the serological tests performed by the laboratory. Because red cell incompatible transfusion reactions occur so infrequently it is difficult to accumulate practical experience in their laboratory presentation and this paper describes several of the pitfalls that may be encountered when laboratory findings deviate from classical descriptions. These include the absence of a positive direct antiglobulin test (Coombs) or an incompatible crossmatch, the absence of any apparent discrepancy between the pre- and post-transfusion specimens in cases of ABO incompatibility, the differentiation of auto-immune haemolytic anaemia from delayed transfusion reactions and the assessment of the clinical significance of any blood group antibodies that may be detected.


Nov 1, 1978·Anaesthesia and Intensive Care·J P Isbister, R D Scurr
Jan 1, 1975·Transfusion·W B Lundberg, M H McGinniss
Jul 1, 1967·Transfusion·R A FranciosiM Santana
May 1, 1980·Anaesthesia and Intensive Care·B H Webster
May 16, 1959·British Medical Journal·J W STEWART, P L MOLLISON
Jan 1, 1961·British Journal of Haematology·F KISSMEYER-NIELSENJ ERSBAK

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hemolytic Anemia

Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. Discover the latest research on AIHA here.

Blood Group Incompatibility

Blood group incompatibility between donor and recipient has been associated with poor transplant outcomes. Discover the latest research on blood group icompatibility here.