The serological screening of deceased tissue donors within the English Blood Service for infectious agents--a review of current outcomes and a more effective strategy for the future

Vox Sanguinis
A D Kitchen, H L Gillan

Abstract

The overall effectiveness of the NHSBT screening programme for infectious agents in deceased tissue donors is examined and evaluated in terms of current outcomes and how to improve upon these outcomes. The screening results and any subsequent confirmatory results from a total of 1659 samples from NHSBT deceased donors referred to NTMRL for screening for infectious agents were included in the analysis. Overall 1566/1659 (94.4%) of the samples were screen negative. A total of 93 were repeat reactive on screening for one or more of the mandatory markers screened for, of which only 12 (13%) were subsequently confirmed to be positive on confirmatory testing. The majority of the repeat reactive samples were demonstrating non-specific reactivity with the screening assays in use. Overall, the NHSBT screening programme for infectious agents in deceased tissue donors is very effective with a relatively low overall loss of donors because of non-specific reactivity. However, unnecessary loss of tissue products is not acceptable, and although this programme compares favourably with the outcomes of other such programmes, the confirmatory results obtained demonstrate both the need and the potential for improving the outcomes. This is particul...Continue Reading

References

Feb 22, 2002·Journal of Medical Virology·Marcel MiédougéJacques Izopet
Nov 26, 2005·Cell and Tissue Banking·D Michael StrongSusan L Stramer
Sep 29, 2006·Transplantation·Dominique ChallineJean-Michel Pawlotsky
Apr 28, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S ThomasA Taylor

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Citations

Jan 29, 2013·Cell and Tissue Banking·A D KitchenH L Gillan
Aug 28, 2019·Cell and Tissue Banking·Jacinto Sánchez IbáñezSilvia Sauleda Oliveras
Nov 28, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Melissa A GreenwaldRichard A Forshee

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