PMID: 9163546Apr 25, 1997Paper

The serotonergic projection from the median raphe nucleus to the suprachiasmatic nucleus modulates activity phase onset, but not other circadian rhythm parameters

Brain Research
E L Meyer-BernsteinL P Morin

Abstract

The suprachiasmatic nucleus (SCN) is densely innervated by serotonergic fibers originating in the median raphe nucleus (MR). Serotonin (5-HT) specific lesions of the MR alter entrainment and eliminate 5-HT fibers in the SCN, as well as in all other MR-recipient areas. The present study used 5-HT specific lesions of the SCN or the MR to determine the role of 5-HT in the SCN as a regulator of entrainment. Neurotoxic lesions of the MR significantly reduced 5-HT cell bodies in that nucleus and eliminated essentially all 5-HT innervation of the SCN. As previously demonstrated, these anatomical changes were associated with an advance in activity onset, delay in offset and expansion of the activity phase (alpha). Neurotoxin directly applied to the SCN caused an advance in the average activity onset, but had no effect on offset or alpha. About half of the SCN lesion animals had onsets equivalent to the MR lesion group, whereas onsets of the remaining animals were normal. Loss of SCN 5-HT innervation was severe for all SCN lesion animals, but significantly greater for those with advanced activity onsets. These results suggest that although the 5-HT projection to the SCN is likely to be responsible for modulating activity onset, the timi...Continue Reading

Citations

Dec 13, 2017·Neural Plasticity·Chelsea A Vadnie, Colleen A McClung
Oct 27, 1998·Chronobiology International·M A Rea
Apr 29, 1999·Annals of Medicine·L P Morin
Aug 8, 2002·Journal of Biological Rhythms·Shin YamazakiMichael Menaker
Jul 8, 2010·The European Journal of Neuroscience·Glenn R Yamakawa, Michael C Antle
Oct 8, 1999·Journal of Biological Rhythms·J Flett, C S Colwell
Nov 4, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Guy Bloch, Avital Meshi
Sep 10, 2014·The European Journal of Neuroscience·Victoria M SmithMichael C Antle
Oct 19, 2017·The European Journal of Neuroscience·Jhenkruthi Vijaya ShankaraMichael C Antle
Apr 23, 2005·The European Journal of Neuroscience·Alfonso AbizaidTamas L Horvath
Sep 26, 2013·Chronobiology International·Erin V Paulus, Eric M Mintz
Oct 7, 2016·Nature·Franz Weber, Yang Dan
Oct 26, 1999·The Journal of Comparative Neurology·K V FiteL Bengston
Oct 13, 2015·The European Journal of Neuroscience·Victoria M SmithMichael C Antle
Apr 6, 2011·Alcoholism, Clinical and Experimental Research·Allison J BragerJ David Glass
Dec 13, 2005·Brain Research Reviews·L P Morin, C N Allen
Oct 9, 2007·Brain Research·Travis C JenkinsElizabeth L Meyer-Bernstein

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