The serotonergic somatosensory projection to the tectum of normal and eyeless salamanders

Journal of Morphology
Edward R Gruberg, William A Harris

Abstract

The spinotectal somatosensory projection was compared in normal, genetically eyeless, and embryonically manipulated salamanders. In normal animals, serotonin fluorescence was restricted to the intermediate tectalneuropil. This same region showed both high levels of serotonin uptake and somatosensory single unit electrical activity. In mutant eyeless salamanders and in normal animals enucleated early in development, serotonin fluorescence, serotonin uptake, and somatosensory activity were present in the superficial tectal neuropil. One-eyed animals, either genetically normal axolotls with one eye enucleated embryonically or genetically eyeless animals in which a normal eye had been transplanted, showed normal intermediate serotonin fluroescence and somatosensory physiology in the visually innervated half-tectum. In the visually uninnervated half-tectum, they showed superficial serotonin fluorescence and somatosensory physiology. In normal animals, 5,7-dihydroxytryptamine (5,7-DHT), a specific poison for serotonergic fibers, eliminated physiological responses in the contralateral somatosensory tectal region. The 5,7-DHT poisoning also abolished U.V.-induced serotonin fluorescence in the intermediate tectal neuropil. These results...Continue Reading

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Citations

Apr 10, 1984·The Journal of Comparative Neurology·T C RitchieR B Leonard
Dec 5, 1998·Journal of Morphology·U Dicke, S Mühlenbrock-Lenter
Mar 16, 2000·The Journal of Comparative Neurology·P BranchereauJ M Cabelguen
Apr 1, 1985·Neuroscience·R M Harris-WarrickJ A Filler

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