The serotonergic system in L-DOPA-induced dyskinesia: pre-clinical evidence and clinical perspective

Journal of Neural Transmission
Manolo Carta, Anders Björklund

Abstract

During the last decade, the serotonergic system has emerged as a key player in the appearance of L-DOPA-induced dyskinesia in animal models of Parkinson's disease. Clinical investigations, based on imaging and postmortem analyses, suggest that the serotonin neurons are also involved in the etiology of this complication of long-term L-DOPA treatment in parkinsonian patients. These findings have stimulated efforts to develop new therapies using drugs targeting the malfunctioning serotonin neurons. In this review, we summarize the experimental and clinical data obtained so far and discuss the prospects for further development of this therapeutic strategy.

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Citations

Aug 18, 2018·The European Journal of Neuroscience·Emma L Lane
Sep 27, 2019·Journal of Movement Disorders·Michael L MartiniFiona Gupta
Nov 7, 2019·Expert Opinion on Therapeutic Patents·Sheilla Da Silva BarrosoMargarete Zanardo Gomes
Jan 8, 2020·International Journal of Molecular Sciences·Abdeslam ChagraouiPhilippe De Deurwaerdère
Feb 7, 2020·Antioxidants·Pavlina Andreeva-GatevaRadka Tafradjiiska-Hadjiolova
Aug 21, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·C Warren OlanowJose A Obeso
May 7, 2021·Journal of Experimental Pharmacology·Andrea Fabbrini, Andrea Guerra

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