The serotonin-2C agonist Lorcaserin delays intravenous choice and modifies the subjective and cardiovascular effects of cocaine: A randomized, controlled human laboratory study

Pharmacology, Biochemistry, and Behavior
Jimmie L PirtleKenneth W Grasing

Abstract

Lorcaserin is a modestly selective agonist for 2C serotonin receptors (5-HT2CR) approved for weight-loss therapy. This class can attenuate cue-induced responding and drug taking in preclinical studies, but effects in humans have not been reported. We evaluated effects of single 10 mg doses of lorcaserin on the subjective and reinforcing effects of cocaine, using a randomized, double-blind, within-subject, cross-over design. Male, non-treatment-seeking, regular cocaine users received either single doses of oral placebo (n = 9) or lorcaserin (n = 9), followed by low- or high- doses of intravenous cocaine (0.23 or 0.46 mg/kg-injection). They were then allowed to self-administer the lower dose of cocaine. Cocaine was well tolerated after lorcaserin pretreatment. Oral lorcaserin did not modify the number of cocaine injections self-administered. However, it prolonged the time over which participants made intravenous choices relative to the duration of monetary (cash) decisions. Lorcaserin increased ratings of 'high' and 'stimulated' after low-dose cocaine or vehicle, but decreased craving for cocaine after intravenous vehicle. It also caused small but significant increases in heart rate following noncontingent injections of intraveno...Continue Reading

Associated Clinical Trials

Feb 11, 2016·KENNETH GRASING

Citations

Feb 7, 2020·Assay and Drug Development Technologies·Hermann A M Mucke
Aug 26, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S Stevens Negus, Matthew L Banks
Jun 5, 2020·Psychopharmacology·Junchao TongStephen J Kish
Oct 8, 2020·Nature Reviews. Neuroscience·Marco VenniroYavin Shaham
Jan 4, 2021·Addiction Biology·Caroline A AroutMargaret Haney
Jan 15, 2020·Cold Spring Harbor Perspectives in Medicine·E Andrew TownsendMatthew L Banks
Apr 17, 2021·Neuropharmacology·Katherine M SerafineEric P Zorrilla
Aug 31, 2021·Pharmacology, Biochemistry, and Behavior·S S Negus, M L Banks

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