PMID: 6981071May 1, 1982Paper

The serotonin autoreceptor: antagonism by quipazine

Neuropharmacology
L L Martin, E Sanders-Bush

Abstract

The purpose of this study was to attempt to reproduce previous findings regarding the antagonist specificity of the 5HT autoreceptor and to find additional antagonists of this receptor. Crude synaptosomal preparations of the rat hypothalamus were loaded with [3H]5HT, placed on glass microfiber filters and superfused with modified Krebs--Henseleit buffer at 37 degrees C. The release of [3H]5HT was stimulated by raising the buffer K+ concentration and was Ca2+-dependent. In the presence of 100 nM fluoxetine (a selective 5HT uptake inhibitor), exogenous 5HT inhibited the K+-induced release of [3H]5HT but did not affected basal [3H]5HT release. The K+-induced [3H]5HT release was maximally inhibited by 30 nM 5HT to a level of 66.4 +/- 4.0% of control. The concentration of 5HT required to inhibit half-maximally K+-induced [3H]5HT release was approx. 7 nM. Methiothepin and quipazine were found to block the inhibition of K+-induced [3H]5HT release by exogenous 5HT (30 nM). The IC50S for blockade of the effects of 5HT were approx. 3.8 and 670 nM for methiothepin and quipazine, respectively. Several other putative 5HT antagonists, the dopamine receptor antagonist, spiperone and the alpha receptor antagonist, phentolamine, were without ef...Continue Reading

References

Aug 15, 1979·European Journal of Pharmacology·F Cerrito, M Raiteri
Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·M Göthert, G Weinheimer
May 1, 1978·Pharmacology, Biochemistry, and Behavior·D M Jacobowitz, J S Richardson
Jul 16, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·M HamonJ Glowinski
May 1, 1976·Life Sciences·R W FullerD T Wong
Mar 1, 1974·European Journal of Pharmacology·M RaiteriG Levi
Aug 1, 1974·The Journal of Pharmacy and Pharmacology·L O Farnebo, B Hamberger
Mar 1, 1980·British Journal of Pharmacology·M J LansdownR G Williams

❮ Previous
Next ❯

Citations

Jan 1, 1984·Psychopharmacology·H J AltmanS O Ogren
Apr 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·S O Ogren, O G Berge
Jan 14, 1986·European Journal of Pharmacology·K A Stauderman, D J Jones
Apr 7, 1987·European Journal of Pharmacology·R F NealeM Williams
Jan 12, 1988·European Journal of Pharmacology·L BrownD Smith
Aug 1, 1987·Journal of the Autonomic Nervous System·H Tatsumi, Y Katayama
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·P Ribeiro, R A Webb
Dec 12, 1996·European Journal of Pharmacology·M R ProwD J Heal
Jan 1, 1990·Annals of the New York Academy of Sciences·M Göthert
Jun 3, 2008·Respiratory Physiology & Neurobiology·Leszek Kubin, Denys V Volgin
Nov 24, 2007·Pharmacology, Biochemistry, and Behavior·Gary A Gudelsky, Bryan K Yamamoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.