The serotonin hypothesis of schizophrenia: a historical case study on the heuristic value of theory in clinical neuroscience

Journal of the History of the Neurosciences
Alan A Baumeister, Mike F Hawkins

Abstract

Clinical examination of the reliability and coherence of the evidence concerning modern neurochemical theories of mental disorders has led some scholars to conclude that support for many of these theories is weak. Nevertheless, these theories continue to be widely promoted. One explanation that has been offered for continued adherence to questionable theory is that it stimulates and gives direction to research. The heuristic value of theory is examined in the present paper by tracing the discoveries that followed from an old theory of schizophrenia, which is--by current consensus--false. It is shown that the original serotonin hypothesis of schizophrenia did, in fact, lead to significant advances in neuropharmacology, neurology and psychiatry.

Citations

Sep 29, 2005·Journal of the History of the Neurosciences·Alan A Baumeister, Mike F Hawkins
Sep 6, 2012·Journal of the History of the Neurosciences·Shai Mulinari
Jul 6, 2014·BioMed Research International·Benjamin RollandRégis Bordet
May 17, 2012·Chemistry & Biodiversity·Jingchun SunZhongming Zhao
Mar 3, 2020·Medicinal Research Reviews·Radomir JuzaJan Korabecny
Apr 25, 2020·Translational Psychiatry·Alexander W CharneyJonathan Xu
Jul 31, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·B DrukarchM M M Wilhelmus

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