The serotonin transporter promoter polymorphism and suicide

Neuroscience Letters
Nicole HelbecquePhilippe Amouyel

Abstract

Serotonergic dysfunction has been implicated in mood disorders and in the pathophysiology of suicidality. A functional polymorphism (a 44-base pair insertion (L)/deletion (S)) in the promoter of the gene encoding the serotonin transporter (5-HTTLPR), associated with mood disorders, has been inconsistently associated with suicidality. To add to this debate, we designed a case-control study involving 62 suicide victims and 72 controls matched for age, gender and ethnicity. All subjects underwent forensic investigation. No association could be detected between the 5-HTTLPR polymorphism and suicide. This result is consistent with the proposal that different genes are involved in hopelessness and suicidal behavior or in depressive illness.

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Citations

Jul 21, 2009·Primary Care Companion to the Journal of Clinical Psychiatry·Nicole S LuddingtonRif S El-Mallakh
Aug 25, 2009·European Psychiatry : the Journal of the Association of European Psychiatrists·L MaurexR Leopardi
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Jun 4, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·D Larry SparksNicole Helbecque
Feb 6, 2014·BMC Psychiatry·Carlos Alfonso Tovilla-ZárateMaría Antonia Jiménez-Santos
Sep 15, 2010·Journal of Psychopharmacology·Xenia GondaZoltan Rihmer

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