The serum biomarker chemerin promotes tumorigenesis and metastasis in oral squamous cell carcinoma

Clinical Science
Zhiyuan LuAnxun Wang

Abstract

Chemerin, which is encoded by retinoic acid receptor responder 2 (RARRES2), has been found to be related to malignant tumours, but its role in the development of oral squamous cell carcinoma (OSCC) is largely unexplored. In the present study, a higher serum level of chemerin was evident in patients with OSCC than in healthy individuals, and this high level of chemerin significantly decreased after tumour resection. In addition, high chemerin levels were positively associated with advanced tumour stage and lymph node metastasis. The expression levels of chemerin and Chemerin Receptor 23 (ChemR23) were positively correlated with the migration and invasion of OSCC cell lines. Recombinant chemerin (R-chemerin) enhanced the in vitro migration, invasion and proliferation of OSCC cells in a concentration-dependent manner, and short hairpin RNAs (shRNAs) targeting RARRES2 decreased chemerin expression and inhibited OSCC cell metastasis and proliferation both in vitro and in vivo Additionally, R-chemerin activated manganese superoxide dismutase (SOD2) and increased the amount of intracellular hydrogen peroxide (H2O2), leading to a significant decrease in E-cadherin expression and dramatic increase in the expression of phosphorylated ERK...Continue Reading

References

Feb 19, 2013·The International Journal of Developmental Biology·Joëlle DupontChristelle Ramé
Jan 29, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Safiye Gonzalvo-FeoSilvano Sozzani
Dec 31, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Francesco Mariani, Luca Roncucci
Jan 13, 2015·The International Journal of Biochemistry & Cell Biology·Zhonghua LiuAnxun Wang
Jul 28, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·David J Ferland, Stephanie W Watts
Sep 13, 2015·Molecular and Cellular Endocrinology·Jillian L RourkeChristopher J Sinal
Dec 3, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Serpil ErdoganErsan Ozaslan
Apr 20, 2016·British Journal of Cancer·J Dinesh KumarAndrea Varro
May 11, 2016·Clinical Oral Investigations·Noha A Ghallab, Olfat G Shaker
Aug 9, 2016·The Journal of Clinical Endocrinology and Metabolism·Daniel P AnderssonPeter Arner
Aug 16, 2016·Postȩpy higieny i medycyny doświadczalnej·Błażej SzydłoZofia Ostrowska
Dec 29, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Erivan S Ramos-JuniorSandra Y Fukada
Jun 19, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ren-Jun PengJian Xi
Nov 8, 2017·Free Radical Biology & Medicine·Ewa JówkoJadwiga Kotowska
Nov 16, 2017·Acta biochimica Polonica·Marzena Zalewska-ZiobZofia Ostrowska
Dec 30, 2017·Interface Focus·Simao LaranjeiraPiotr Orlowski
Feb 8, 2018·Cytokine·Elisabeth M HaberlChrista Buechler
Mar 9, 2018·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Jingjing SunAnxun Wang
Jun 2, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephanie ZyllaNele Friedrich
Jul 22, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Petra NiklowitzThomas Reinehr
Aug 22, 2018·International Journal of Molecular Sciences·Karla Bianca NevesRita C Tostes
Nov 16, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·George P SotiropoulosAthanasios G Papavassiliou
Jan 5, 2019·Physical Review Letters·D AdeyUNKNOWN Daya Bay Collaboration

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Citations

Jul 3, 2019·The Journal of Clinical Investigation·Yihai Cao
Aug 19, 2020·Biomarkers in Medicine·Xiaolong QiYingjun Li
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Maria M HaykalOcéane C B Martin
Mar 24, 2021·Scientific Reports·Yanfang SongDan Wen
Jan 21, 2022·Future Oncology·Kairui LuMeilin Ru

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