The serum inhibin B concentration and reference ranges in normozoospermia

European Journal of Endocrinology
Anne-Laure BarbotinValerie Mitchell

Abstract

Although an inhibin B assay may be useful in the assessment of testicular function in a number of genital conditions, reliable reference ranges are still lacking. The present study sought to establish the reference range for serum inhibin B by applying the updated Gen II assay. This prospective study included 818 men referred for semen analysis: 377 were normozoospermic (reference group) and 441 presented at least one abnormal semen parameter (case group). Semen parameters were interpreted according to the 2010 World Health Organization manual and David's modified classification for normal morphology. The inhibin B concentration was determined with the current ELISA. In the reference group, the 2.5th percentile for inhibin B was 92 pg/ml and the 97.5th percentile for FSH was 7.8 IU/l. In the overall population, an inhibin B level <92 pg/ml was associated with increased odds ratio (OR; 95% CI) for oligozoospermia (16.93 (9.82-29.18), P<0.0001), asthenozoospermia (4.87 (2.88-8.10), P<0.0001), and teratozoospermia (2.20 (1.31-3.68), P=0.0026). The combination of a FSH >7.8 IU/l and an inhibin B <92 pg/ml was associated with greater OR for oligozoospermia (98.74 (23.99-406.35), P<0.0001) than for each hormone considered separately....Continue Reading

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Citations

Apr 15, 2016·PloS One·Thomas W KelseyW Hamish B Wallace
Aug 31, 2018·Andrologia·Anne-Laure BarbotinValerie Mitchell
Oct 5, 2018·Animals : an Open Access Journal From MDPI·Viviana BravoGerardo Acosta-Jamett
Jun 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Andrew A DwyerRavikumar Balasubramanian
Dec 23, 2016·Human Reproduction·Florence BelvaMaryse Bonduelle
Feb 14, 2018·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Flaminia FanelliAntonio Balsamo
Feb 13, 2020·International Journal of Reproductive Medicine·Tchoula Mamiafo CorinneNgogang Yonkeu Jeanne
Jan 28, 2021·Clinical Endocrinology·Anna Paloma M R RibeiroJosé de Bessa
May 4, 2021·Frontiers in Endocrinology·Jingyi WenShixuan Wang

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