The serum neutralizing antibody response in cattle to Fusobacterium necrophorum leukotoxoid and possible protection against experimentally induced hepatic abscesses

Veterinary Research Communications
S SaginalaP M Hine

Abstract

The serum antileukotoxin antibody response and protection against subsequent experimental challenge with Fusobacterium necrophorum were investigated in 30 steers vaccinated with crude F. necrophorum leukotoxoid. Culture supernatant of F. necrophorum, strain 25, containing leukotoxoid was concentrated. The steers were assigned randomly to six groups (n = 5): PBS control with Stimulon adjuvant; vaccinated with concentrated supernatant diluted to provide 2.5, 5.0, 10.0, or 20.0 ml with the water-soluble Stimulon adjuvant; and 5.0 ml with the Ribi oil-emulsion adjuvant. The steers were injected subcutaneously on days 0 and 21. Blood samples were collected at weekly intervals to monitor serum antileukotoxin antibody titres. On day 42, all the steers were challenged intraportally with F. necrophorum culture. Three weeks later (day 63), the steers were killed and necropsied for examination of their livers and assessment of protection. Steers vaccinated with crude leukotoxoid tended to have higher antileukotoxin titres than the controls, but the difference was not significant. Also, the antibody titre did not appear to be dose-dependent. In the control group, 3 out of 5 steers developed liver abscesses. The incidence of liver abscesses...Continue Reading

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Citations

Dec 26, 2001·Veterinary Microbiology·Sanjeev Kumar NarayananGeorge C Stewart
Aug 14, 2001·Infection and Immunity·S K NarayananG C Stewart
Jul 16, 2002·Infection and Immunity·Sanjeevkumar NarayananT G Nagaraja
May 15, 2010·The Journal of Veterinary Medical Science·Cheng-Chung LinJacky Peng-Wen Chan
Oct 30, 2003·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Manuel Chirino-TrejoFei Huang
Oct 15, 2009·The Veterinary Clinics of North America. Food Animal Practice·Ueli Braun
Jul 4, 2007·The Veterinary Clinics of North America. Food Animal Practice·T G Nagaraja, Kelly F Lechtenberg

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