PMID: 18199343Jan 18, 2008Paper

The seven-year preliminary results of brachytherapy with Iodine-125 seeds for localized prostate cancer treated at a Brazilian single-center

International Braz J Urol : Official Journal of the Brazilian Society of Urology
Carlos A S FrancaAntonio B R Penna

Abstract

To report the seven-year preliminary results of a single-center on brachytherapy with Iodine-125 seeds, used in combination with external beam radiotherapy in selected patients with localized prostate cancer (T1-T2). All 105 patients treated by brachytherapy with Iodine-125 seeds, from January/1998 to December/2004, were retrospectively analyzed. The prescribed dose was 144 Gy at the periphery of the prostate for isolated brachytherapy, and 110 Gy for the combination with external beam radiotherapy. The external beam radiotherapy dose was 45 Gy, at the prostatic bed. Neoadjuvant hormone therapy was indicated for selected patients, who received luteinizing hormone-releasing hormone (LH-RH) and/or antiandrogens. For definition of biochemical relapse, it was adopted the American Society for Therapeutic Radiology and Oncology consensus. Of the 105 patients treated, 90 were followed for a mean period of 70 months. Biochemical disease control was achieved in 62 (69%) and biochemical recurrence was manifested in 28 (31%). The analysis of each risk group showed biochemical disease control rates of 79%, 71% and 52% in the low, intermediate and high risk groups, respectively. The mean time for biochemical recurrence was 22 months. Genito...Continue Reading

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Dec 23, 2009·The Journal of Laryngology and Otology·J-P VezinaG Fradet
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Oct 29, 2009·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Carlos A S FrancaAntonio B R Penna
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