The severe COVID-19: A sepsis induced by viral infection? And its immunomodulatory therapy

Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi
Hong-Yuan Lin

Abstract

COVID-19 is known for its magical infectivity, fast transmission and high death toll based on the large number of infected people. From the perspective of the clinical manifestation, autopsy examination and pathophysiology, the essence of COVID-19 should be viewed as a sepsis induced by viral infection, and has the essential characteristics as sepsis induced by other pathogens. Therefore, in addition to etiological and supportive treatment, immunomodulatory therapy is also appropriate to severe COVID-19. Although there is still a lack of consensus on immunotherapy for sepsis so far, relatively rich experiences have been accumulated in the past decades, which will help us in the treatment of severe COVID-19. This article will elaborate immunotherapy of sepsis, though it may not be consistent.

Citations

Dec 31, 2020·International Journal of Molecular Sciences·Uli Binder, Arne Skerra
Feb 23, 2021·Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi·Wen-Jun ZhaoLei Li
Oct 15, 2020·Medicina·Antonio Mirijello On Behalf Of The Internal Medicine Sepsis Study Group
Aug 3, 2021·Frontiers in Pharmacology·Guyi WangYanjun Zhong

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NCT04321096
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