The Severity of Injury and the Extent of Hemorrhagic Shock Predict the Incidence of Infectious Complications in Trauma Patients

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
Thomas LustenbergerM Keel

Abstract

Trauma patients are at high risk of developing systemic inflammatory response syndrome (SIRS) and infections. The aim of this study was to evaluate the influence of the severity of injury and the extent of hemorrhagic shock at admission on the incidence of SIRS, infection and septic complications. A total of 972 patients who had an injury severity score (ISS) of ≥ 17, survived more than 72 h, and were admitted to a level I trauma center within 24 h after trauma were included in this retrospective analysis. SIRS, sepsis and infection rates were measured in patientswith different severities of injury as assessed by ISS, or with various degrees of hemorrhagic shock according to ATLS(®) guidelines, andwere compared using both uni- and multivariate analysis. Infection rates and septic complications increase significantly (p < 0.001) with higher ISS. Severe hemorrhagic shock on admission is associated with a higher rate of infection (72.8%) and septic complications (43.2%) compared to mild hemorrhagic shock (43.4%, p < 0.001 and 21.7%, p < 0.001, respectively). The severity of injury and the severity of hemorrhagic shock are risk factors for infectious and septic complications. Early diagnostic and adequate therapeutic work up with p...Continue Reading

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Citations

Nov 1, 2011·World Journal of Surgery·Thomas LustenbergerMarius J B Keel
Dec 1, 2012·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·L MicaO Trentz
May 21, 2013·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·Joanne M MinnickRosemarie Ramirez
Apr 25, 2012·Mediators of Inflammation·Birgit AunerBorna Relja
Oct 16, 2019·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Borna Relja, Walter Gottlieb Land
Feb 5, 2011·Current Opinion in Anaesthesiology·Kathelijne M GroeneveldJozef Kesecioglu

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