PMID: 6413857Oct 1, 1983Paper

The sex-linked recessive lethal test for mutagenesis in Drosophila melanogaster. A report of the U.S. Environmental Protection Agency Gene-Tox Program

Mutation Research
W R LeeS Zimmering

Abstract

The test for sex-linked recessive lethals (SLRL) in Drosophila melanogaster has been used to detect induced mutations since 1927. The advantage of the test for both screening and hazard evaluation is its objectivity in testing for transmissible mutations in the germ cells of a eukaryote. Statistical criteria for both positive and negative mutagenicity at the highest concentration tested under a particular exposure condition were developed by the Work Group, and a recommended protocol for future testing was agreed upon. For 421 compounds there were sufficient data available in the literature for analysis; 198 compounds were found to be positive and 46 negative at the highest concentration tested. Most experiments had been done for objectives of pure research rather than for deliberately screening for mutagenicity, although many of the 421 chemicals were selected for testing because of suspected mutagenicity. Therefore, the statement of 198 positive and 46 negative should not be taken as an example of the proportion of mutagens in the environment. In three sets of experiments with D. melanogaster that were done specifically for screening, one involving 40 compounds for the Environmental Protection Agency (EPA), the others involvi...Continue Reading

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Citations

Nov 1, 1980·Archives of Toxicology·F E Würgler
Sep 1, 1988·Mutation Research·I QuintoN Staiano
Aug 1, 1995·Mutation Research·E W Vogel, A T Natarajan
Jun 12, 1996·Mutation Research·C RamelS Consuegra
Jan 1, 1986·Mutation Research·S ZimmeringC Osgood
Jan 1, 1991·IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
May 1, 1988·Mutation Research·F K EnneverH S Rosenkranz
Apr 1, 1989·Mutation Research·U GrafF E Würgler
Jun 1, 1991·Mutation Research·N K Tripathy, K K Patnaik
Jan 1, 1994·Mutation Research·H W Leung
Jan 1, 1995·Mutation Research·M Batiste-AlentornR Marcos
Sep 1, 1984·Mutation Research·H S RosenkranzY Y Haimes

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