The SF3b complex: splicing and beyond.

Cellular and Molecular Life Sciences : CMLS
Chengfu Sun

Abstract

The SF3b complex is an intrinsic component of the functional U2 small nuclear ribonucleoprotein (snRNP). As U2 snRNP enters nuclear pre-mRNA splicing, SF3b plays key roles in recognizing the branch point sequence (BPS) and facilitating spliceosome assembly and activation. Since the discovery of SF3b, substantial progress has been made in elucidating its molecular mechanism during splicing. In addition, numerous recent studies indicate that SF3b and its components are engaged in various molecular and cellular events that are beyond the canonical role in splicing. This review summarizes the current knowledge on the SF3b complex and highlights its multiple roles in splicing and beyond.

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S M BergetP A Sharp
Dec 15, 1994·Genes & Development·A M MacMillanP A Sharp
Jul 22, 1998·Molecular and Cellular Biology·W SeghezziE Lees
Jun 11, 2002·Biochemical and Biophysical Research Communications·R TrappeW Engel
Jul 10, 2002·The Journal of Biological Chemistry·An BoudrezMathieu Bollen
Jul 3, 2004·Genes & Development·Clara L KielkopfMichael R Green
Apr 11, 2006·The Journal of Biological Chemistry·Erica CavellánAnn-Kristin Ostlund Farrants
Jun 23, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Autumn MassielloCharles E Chalfant
Sep 9, 2008·Nature Immunology·Sho YamasakiTakashi Saito
Nov 26, 2009·Nature Structural & Molecular Biology·Zbigniew WarkockiReinhard Lührmann
Oct 11, 2011·The FEBS Journal·Akira YokoiYoshiharu Mizui

❮ Previous
Next ❯

Citations

Jul 28, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Carme Nuño-Cabanes, Susana Rodríguez-Navarro
Feb 9, 2021·Journal of Plant Research·Shiori S AkiTomohiko Tsuge
Dec 5, 2020·Trends in Biochemical Sciences·Francesca De BortoliRui Zhao
Dec 11, 2020·RNA·Rosario Prados-CarvajalPablo Huertas
May 7, 2021·Communications Biology·Haroon ButtMagdy M Mahfouz
Jun 12, 2021·Epigenetics & Chromatin·Ying-Jiun C Chen, Sharon Y R Dent

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy
electrophoresis
acetylation
pull-down
immunoprecipitation
two-hybrid
co-immunoprecipitation
electrophoretic mobility shift assay

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

© 2021 Meta ULC. All rights reserved