PMID: 9552170Apr 29, 1998Paper

The shaking B gene in Drosophila regulates the number of gap junctions between photoreceptor terminals in the lamina

Journal of Neurobiology
M Shimohigashi, Ian A Meinertzhagen

Abstract

The molecular structure of insect gap junctions differs from that in vertebrates, and in Drosophila is possibly encoded by the shaking B (= Passover) locus. shaking B2 is a null allele that acts in the nervous system. In the shakB2 mutant, one site of action are gap junctions between photoreceptor terminals in the cartridges of the lamina, beneath the compound eye, which we assayed from the number of close-apposition profiles in thin-section EM. The number of profiles in the Canton-S (C-S) wild type is about 0.5 per cartridge per section in distal and mid-lamina depths, and significantly less, about one quarter this value, closer to the brain, in the proximal lamina. In shakB2, there are fewer profiles, approximately one quarter the number of appositions in distal and mid-lamina depths as in C-S, and their number does not differ significantly from those at the proximal depth in either the mutant or wild type. Thus mutant action is associated with a reduced number of appositions at distal and mid-lamina depths. We propose that R1-R6 gap junctions are partitioned into at least two strata, proximal and distal, and that two populations of gap junctions exist, one extending throughout the lamina that does not require shakB, and a se...Continue Reading

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Citations

May 8, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P Phelan, T A Starich
Jul 13, 2013·Cell Death & Disease·Y YangL Liu
Jan 27, 2006·Molecular Biology of the Cell·Corinna LehmannMichael Hoch
Jul 24, 2008·Cell Communication & Adhesion·Katinka OstrowskiMichael Hoch
Jul 2, 2003·The Journal of Comparative Neurology·J Górska-AndrzejakI A Meinertzhagen
Aug 10, 1999·Journal of Neurobiology·Z ZhangR J Wyman
Aug 30, 2005·The Journal of Comparative Neurology·Elena Sivan-Loukianova, Daniel F Eberl
Sep 2, 2016·Developmental Neurobiology·I Martha Skerrett, Jamal B Williams
Apr 19, 2002·Mechanisms of Development·Lucy A StebbingsJane A Davies
Jun 1, 2005·Biochimica Et Biophysica Acta·Pauline Phelan

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