PMID: 9178432May 1, 1997Paper

The sheep kidney contains a novel unidirectional, high affinity NADP(+)-dependent 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD-3)

Steroids
E P Gomez-SanchezC E Gomez-Sanchez

Abstract

The 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) enzymes convert corticosterone and cortisol to 11-dehydrocorticosterone and cortisone, and are thought to convey extrinsic specificity to the mineralocorticoid receptor by limiting access of the relatively more abundant glucocorticoids to it. Two different 11 beta-hydroxysteroid dehydrogenases (11 beta-HSD) have been described and cloned. The liver-type, NADP(+)-dependent 11 beta-HSD-1, has an affinity in the micromolar range and bidirectional activity. The NAD(+)-dependent 11 beta-HSD-2 has a higher affinity, in the nanomolar range, and exhibits only oxidase activity. 11 beta-HSD-2, because of its affinity and co-localization with the mineralocorticoid receptor, is likely to serve as the "gatekeeper" for the mineralocorticoid receptor in the kidney. Although the rat kidney expresses both isoforms, only the high-affinity, NAD(+)-dependent 11 beta-HSD-2 has been reported in the sheep kidney. We found both 11 beta-HSD NAD(+)- and NADP(+)-dependent activities in sheep kidney to be present. The NAD(+)-dependent activity exhibited a Km similar to that reported in the literature, 3.85 +/- 1.28 nM for corticosterone and 21.3 +/- 5.8 for cortisol, was distributed in approximately e...Continue Reading

References

Nov 1, 1979·The Journal of Clinical Endocrinology and Metabolism·S UlickM I New
Apr 1, 1977·The Journal of Clinical Endocrinology and Metabolism·S UlickM I New
Jul 1, 1988·The Journal of Clinical Investigation·P M StewartC R Edwards
Dec 1, 1969·The Journal of Clinical Endocrinology and Metabolism·L KornelA Hill
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·Z S Krozowski, J W Funder
Nov 1, 1994·Molecular and Cellular Endocrinology·A L AlbistonZ S Krozowski
Jun 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·K Yang, M Yu
Oct 1, 1993·European Journal of Clinical Investigation·J R Seckl
Aug 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·P H JellinckR R Sakai
Mar 1, 1995·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·N M Kaplan
Dec 7, 2011·Indian Journal of Endocrinology and Metabolism·Nisha Bhavani

❮ Previous
Next ❯

Citations

Jun 3, 2004·Cancer Letters·Sárka ZbánkováJirí Pácha
Sep 29, 2001·Steroids·E P Gomez-SanchezC E Gomez-Sanchez
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·Z KrozowskiK E Sheppard
Jul 11, 2009·Neuroendocrinology·Elise P Gomez Sanchez
Nov 28, 2007·Endocrinology·Elise P Gomez-SanchezCelso E Gomez-Sanchez
Jan 22, 2005·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Karla MazancováJirí Pácha
Jun 9, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Victoria SharpAnthony E Michael
Jul 30, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Jana VitkuRichard Hampl
Dec 9, 2016·The Journal of Endocrinology·Maria TsachakiAlex Odermatt
Feb 7, 1998·Hypertension·H M KubischE P Gómez-Sánchez
Aug 4, 2009·Experimental Physiology·Elise P Gomez-Sanchez
Aug 1, 2013·Physiological Reviews·Karen ChapmanJonathan Seckl
Jul 25, 2013·Molecular and Cellular Biochemistry·Shuji OhnoShizuo Nakajin
Sep 14, 1999·The American Journal of Physiology·K E SheppardD J Autelitano
Aug 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·K E SheppardZ S Krozowski
Apr 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Elise P Gomez-SanchezCelso E Gomez-Sanchez
Feb 20, 2021·Molecular and Cellular Endocrinology·Elise P Gomez-Sanchez, Celso E Gomez-Sanchez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.