PMID: 3383853Jun 1, 1988Paper

The sheep metallothionein gene family. Structure, sequence and evolutionary relationship of five linked genes

European Journal of Biochemistry
M G PetersonJ F Mercer

Abstract

Southern blot analysis of the sheep genome revealed a metallothionein gene family with at least nine members. Two overlapping cosmid clones spanning approximately 67 kb and containing five metallothionein genes have been isolated. DNA sequence analysis reveals that one of these is a metallothionein II variant, three are metallothionein I variants and one is a truncated metallothionein pseudogene containing only the first exon. The predicted amino acid sequence was compared with previously reported amino acid composition data of sheep metallothioneins [Whanger, P. D., Oh, S.-H. & Deagen, J. T. (1981) J. Nutr. 111, 1207-1215], and this suggests that we have isolated the genes encoding the major protein isoforms found in the sheep liver. The promoter regions of these genes contain many conserved elements, among them metal-regulatory elements and putative glucocorticoid-responsive elements. However, there are a number of differences between these genes in the arrangement of these elements. Sequence comparisons indicate that the multiple metallothionein I genes and the pseudogene appear to have resulted from sequential duplication events, and a larger cluster of metallothionein I genes may have been disrupted leading to the formatio...Continue Reading

References

Jun 1, 1988·European Journal of Biochemistry·M G Peterson, J F Mercer
Nov 3, 1986·European Journal of Biochemistry·M G Peterson, J F Mercer
Jul 1, 1984·Molecular and Cellular Biology·P F SearleR D Palmiter
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G W StuartR D Palmiter
Oct 25, 1980·Journal of Molecular Biology·F SangerB A Roe
Jan 1, 1983·Methods in Enzymology·J Messing
Sep 17, 1984·European Journal of Biochemistry·M G PetersonJ F Mercer
Jan 1, 1981·Annual Review of Biochemistry·R Breathnach, P Chambon
Mar 1, 1982·Gene·N Hu, J Messing

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Citations

Jul 1, 1995·The Proceedings of the Nutrition Society·I Bremner, J H Beattie
Apr 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A F HollowayA K West
Nov 1, 1994·General Pharmacology·M Ebadi, P L Iversen
Jul 1, 1995·Neurochemistry International·M EbadiR F Pfeiffer
Feb 13, 2003·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Arnaud TanguyDario Moraga
Apr 9, 2008·Journal of Psychiatric Research·Ana Raquel MesquitaNuno Sousa
Jun 1, 1988·European Journal of Biochemistry·M G Peterson, J F Mercer
Nov 24, 2006·Journal of Animal Science·J P WuM A Brown
Feb 19, 1993·Journal of Chromatography·J H BeattieR Self
Mar 1, 1993·Applied and Environmental Microbiology·Z LeishK A Ward
Feb 1, 1996·Molecular and Cellular Biology·E Suh, P G Traber

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