PMID: 6162922Feb 1, 1980Paper

The short term accumulation of axonally transported organelles in the region of localized lesions of single myelinated axons

Journal of Neurocytology
R S Smith

Abstract

Myelinated axons were isolated from the sciatic nerve of Xenopus laevis and were subjected to localized (less than 30 microns wide) lesions. In axons which were bathed in a 0.12 M potassium glutamate solution there was very little local reaction to the lesion and optically-detectable particles undergoing axoplasmic transport accumulated immediately adjacent to, and mostly distal to, the lesion. Preparations fixed for electron microscopy at times up to 3 h following the lesion showed that the axoplasmic changes about the lesion were asymmetrical. Large organelles predominated on the distal side of the lesion; these were mostly dense lamellar bodies (DLB) with mean dimensions, as determined from thin sections, of 0.48 by 0.19 microns. Multivesicular bodies, mitochondria, and a variety of smaller membrane bounded bodies also appeared in the particle accumulation distal to the lesion. Analysis of these results led to the conclusion that DLB were transported up to the lesion and represent the majority of the optically detectable particles which are transported in the retrograde direction. Small vesicles and tubules were the commonest structures which accumulated proximal to the lesion. The time course of this accumulation was consis...Continue Reading

References

Jan 1, 1975·Advances in Comparative Physiology and Biochemistry·J P Heslop
Dec 1, 1976·General Pharmacology·M A Bisby
Mar 1, 1977·Journal of Neuropathology and Experimental Neurology·J W GriffinD B Drachman
Dec 1, 1976·Canadian Journal of Physiology and Pharmacology·R S Smith, Z J Koles
Jan 1, 1978·Annual Review of Pharmacology and Toxicology·K Kristensson
Apr 1, 1978·The Journal of Physiology·L Kovács, M F Schneider
May 1, 1972·Canadian Journal of Physiology and Pharmacology·R S Smith
Oct 1, 1972·The Journal of General Physiology·L M PartlowD B McDougal
May 1, 1973·Archives of Neurology·J B Kirkpatrick, L Z Stern
Jan 1, 1973·Progress in Neurobiology·P L Jeffrey, L Austin
Oct 1, 1974·The Journal of Physiology·P D Cooper, R S Smith
Jan 1, 1973·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M R Matthews
Apr 14, 1970·Brain Research·A J Martinez, R L Friede
Mar 11, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·K Kapeller, D Mayor
Mar 11, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·K Kapeller, D Mayor
Jun 1, 1973·Journal of Neurocytology·P S Spencer, H H Schaumburg
Dec 15, 1967·Science·D M Derry, L S Wolfe
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·J ZelenáE Gutmann
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·J Zelená
Oct 1, 1971·Journal of Neurochemistry·A Hamberger, L Svennerholm
Dec 1, 1965·The Journal of Cell Biology·E Holtzman, A B Novikoff
Feb 1, 1967·Biochimica Et Biophysica Acta·E G LapetinaE de Robertis
Oct 1, 1960·The Journal of Biophysical and Biochemical Cytology·N CAUNA, L L ROSS
Jan 1, 1963·Journal of Neuropathology and Experimental Neurology·S SAMUELSM WEISS
Oct 1, 1964·Journal of Neuropathology and Experimental Neurology·B J WALLACES S LAZARUS

❮ Previous
Next ❯

Citations

Jun 1, 1983·Journal of Neurocytology·M H Ellisman, J D Lindsey
Mar 1, 1991·Journal of Neurocytology·W L MaxwellM Sturatis
Apr 1, 1982·Journal of Neurocytology·A M Mercurio, E Holtzman
Aug 1, 1981·Journal of Neurocytology·D Bray, M B Bunge
Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
Jan 1, 1985·Comparative Biochemistry and Physiology. A, Comparative Physiology·N V OrsonG A Kerkut
Jan 1, 1982·Neuroscience·S TsukitaH Ishikawa
Jan 11, 1990·Neuroscience·S Ochs, R A Jersild
Jun 1, 1989·Brain Research Bulletin·S AranedaA Calas
Aug 1, 1985·The Journal of Cell Biology·T A SchroerR B Kelly
Jul 1, 1991·The Journal of Cell Biology·N HirokawaS T Brady
Jan 1, 1993·The Journal of Cell Biology·G S BloomS T Brady
Sep 1, 1982·The Journal of Cell Biology·B J Schnapp, T S Reese
Apr 4, 1998·Molecular Biology of the Cell·Z Yang, L S Goldstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.