The short-term impact of albendazole treatment on Oesophagostomum bifurcum and hookworm infections in northern Ghana

Annals of Tropical Medicine and Parasitology
Juventus ZiemAnton M Polderman

Abstract

In November-December 2002, stool samples from a random sample of the human population (N = 190) in the Garu area of northern Ghana were checked for intestinal helminths, using a single Kato smear and duplicate coprocultures for each subject. All 190 subjects were subsequently treated with a single, 400-mg dose of albendazole and 146 of them were successfully re-examined 21-28 days post-treatment. Prior to treatment, 75.5% of the Kato smears were found to contain 'hookworm-like' eggs (with a geometric mean egg count among the positives of 578 eggs/g faeces), and the third-stage larvae of Oesophagostomum bifurcum and hookworm were found in the cultures of stools from 34.2% and 77.4% of the subjects, respectively. Among the subjects who had positive Kato smears before treatment, albendazole treatment led to a cure 'rate' of 79.0% and an egg-reduction 'rate' of 73.5%. The results from the coprocultures indicated cure 'rates' of 98.0% for O. bifurcum but only 51.3% for hookworm. Only one subject was still positive for O. bifurcum after treatment. Among those still positive for hookworm after treatment, the larva-reduction 'rate' was 79.8%. The egg-/larva-reduction 'rates' among those with heavy infections prior to treatment were >90...Continue Reading

References

Mar 1, 1991·The American Journal of Tropical Medicine and Hygiene·A M PoldermanP Gigase
Jan 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·H P KrepelA M Polderman
Jul 18, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·P A StoreyP Magnussen

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Citations

Nov 10, 2012·Biodemography and Social Biology·David Van BodegomRudi G J Westendorp
Jun 19, 2013·PloS One·Hernando Sanchez-FaddeevPeter de Knijff
Oct 24, 2006·Tropical Medicine & International Health : TM & IH·Juventus B ZiemAnton M Polderman
Dec 20, 2005·Tropical Medicine & International Health : TM & IH·Lisette van LieshoutA M Polderman

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