PMID: 11334195May 4, 2001Paper

The side-effects of cardiopulmonary bypass on the lungs: changes in bronchoalveolar lavage fluids

Perfusion
I AlatA Veral

Abstract

Although technical refinements have improved the safety of cardiac operations, postoperative dysfunction of lung and other organs occurs frequently after cardiopulmonary bypass (CPB). The aim of the present study was to search the aetiopathogenesis of pulmonary complications due to CBP. Ten patients with stable coronary artery disease, undergoing coronary artery bypass grafting (CABG) surgery, were included in the study. Forty bronchoalveolar lavage (BAL) fluid samplings were performed in the 10 patients. Samples were obtained at the following time periods: (1) preoperatively; (2) at the end of the first hour after anaesthetic induction; (3) at the conclusion of 30 min of crossclamp on CPB; and (4) at the conclusion of 20 h after the end of CPB, postoperatively. Cell contents of bronchoalveolar lavage fluid, alveolar macrophage viability, eosinophil cationic protein (ECP) levels and myeloperoxidase (MPO) concentrations were analysed in each bronchoalveolar lavage fluids. While the percentage of preoperative macrophages was 85.90% and the percentage of preoperative neutrophils was 2.40%, they were 77.00% and 11.30% in the postoperative samples, respectively. Mean alveolar macrophage viability was 96.20% preoperatively and 90.40%...Continue Reading

References

Sep 1, 1977·Anaesthesia·T V GnanaduraiE Welman
Sep 1, 1992·Critical Care Medicine·P D MacnaughtonT W Evans
Jan 1, 1990·Respiration; International Review of Thoracic Diseases·S MarcatiliM Cotrufo
Jan 1, 1987·Scandinavian Journal of Thoracic and Cardiovascular Surgery·E FosseA O Aasen
Feb 26, 1981·The New England Journal of Medicine·D E ChenowethJ W Kirklin
Sep 1, 1994·Clinical Nuclear Medicine·N V BudihnaM Malovrh

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Citations

May 6, 2008·The Journal of Thoracic and Cardiovascular Surgery·B J EvansK M Taylor
Oct 15, 2011·The Heart Surgery Forum·Ufuk TütünSalih Fehmi Katircioglu
Apr 12, 2012·Journal of Cardiovascular Pharmacology and Therapeutics·Kun LiuQing-Sheng You

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