The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.

The Journal of Biological Chemistry
Weimin C HongJonathan L Katz

Abstract

The dopamine transporter (DAT) regulates dopamine (DA) neurotransmission by recapturing DA into the presynaptic terminals and is a principal target of the psychostimulant cocaine. The sigma-1 receptor (σ1R) is a molecular chaperone, and its ligands have been shown to modulate DA neuronal signaling, although their effects on DAT activity are unclear. Here, we report that the prototypical σ1R agonist (+)-pentazocine potentiated the dose response of cocaine self-administration in rats, consistent with the effects of the σR agonists PRE-084 and DTG (1,3-di-o-tolylguanidine) reported previously. These behavioral effects appeared to be correlated with functional changes of DAT. Preincubation with (+)-pentazocine or PRE-084 increased the Bmax values of [3H]WIN35428 binding to DAT in rat striatal synaptosomes and transfected cells. A specific interaction between σ1R and DAT was detected by co-immunoprecipitation and bioluminescence resonance energy transfer assays. Mutational analyses indicated that the transmembrane domain of σ1R likely mediated this interaction. Furthermore, cysteine accessibility assays showed that σ1R agonist preincubation potentiated cocaine-induced changes in DAT conformation, which were blocked by the specific σ...Continue Reading

References

Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M P KavanaughE Weber
Jan 1, 1993·Annual Review of Neuroscience·S G Amara, M J Kuhar
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M HannerH Glossmann
May 19, 2001·The Journal of Biological Chemistry·N KedeiP M Blumberg
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·H HastrupJ A Javitch
May 15, 2003·The Journal of Biological Chemistry·Tatiana SorkinaAlexander Sorkin
Nov 13, 2003·European Journal of Pharmacology·Harald H Sitte, Michael Freissmuth
Mar 6, 2004·The Journal of Biological Chemistry·Junkang XuJian-Ting Zhang
Dec 7, 2007·Cancer Research·Christopher P PalmerEbru Aydar
Sep 18, 2009·The Journal of Biological Chemistry·Denis SohyJean-Yves Springael
Nov 7, 2009·The Journal of Pharmacology and Experimental Therapeutics·Takato HiranitaJonathan L Katz
Apr 8, 2010·Biophysical Journal·Stewart M CarnallyJ Michael Edwardson
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Gemma NavarroRafael Franco
Nov 6, 2010·Current Topics in Medicinal Chemistry·Sanju NarayananChristopher R McCurdy
Jul 15, 2011·Pharmacological Reviews·Anders S KristensenUlrik Gether
Feb 1, 2012·Current Pharmaceutical Design·Matthew J RobsonRae R Matsumoto
Aug 3, 2012·Journal of Medicinal Chemistry·Michelle L JamesFrederick T Chin
Sep 7, 2012·The Journal of Biological Chemistry·Dilshan BalasuriyaJ Michael Edwardson
Oct 30, 2012·Trends in Neurosciences·Saïd KourrichAntonello Bonci
Nov 29, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Takato HiranitaJonathan L Katz
Aug 24, 2013·Trends in Pharmacological Sciences·Roxanne A Vaughan, James D Foster
May 23, 2014·The Journal of Biological Chemistry·Katarzyna A GromekBrian G Fox
Sep 27, 2015·Pharmacological Reviews·Christopher L GermanAnnette E Fleckenstein
Dec 10, 2015·Behavioural Pharmacology·Jonathan L KatzTsung-Ping Su
Apr 5, 2016·Nature·Hayden R SchmidtAndrew C Kruse
May 4, 2016·Basal Ganglia·David SulzerMargaret E Rice
May 18, 2016·The Journal of Pharmacology and Experimental Therapeutics·Jonathan L KatzChristopher R McCurdy
Sep 4, 2016·Pharmacological Reviews·Daniel P Bermingham, Randy D Blakely

❮ Previous
Next ❯

Citations

Dec 22, 2017·Nature Communications·Danielle O SamboHabibeh Khoshbouei
Mar 3, 2019·The Journal of Biological Chemistry·Joseph J LebowitzHabibeh Khoshbouei
Apr 27, 2017·The Journal of Pharmacology and Experimental Therapeutics·Takato HiranitaJonathan L Katz
Feb 16, 2020·The Journal of Pharmacology and Experimental Therapeutics·Weimin Conrad Hong
Oct 15, 2019·Frontiers in Neuroscience·Daniel A RyskampIlya Bezprozvanny
Sep 21, 2018·Frontiers in Pharmacology·Vincent M LamAli Salahpour
Oct 7, 2018·Nature Structural & Molecular Biology·Hayden R SchmidtAndrew C Kruse
Jul 2, 2019·Frontiers in Pharmacology·Sema G QuadirValentina Sabino
Sep 26, 2019·Frontiers in Neuroscience·Daniel A RyskampIlya Bezprozvanny
Oct 9, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·I P AlonsoR A España
Feb 15, 2020·Computational and Structural Biotechnology Journal·Ara M AbramyanLei Shi
Aug 8, 2019·Trends in Pharmacological Sciences·Hayden R Schmidt, Andrew C Kruse
Jan 19, 2021·Molecular Neurobiology·Shao-Ming WangHsiang-En Wu
Sep 5, 2020·ACS Chemical Neuroscience·Carlo CifaniMaria Vittoria Micioni Di Bonaventura
Jul 16, 2020·The International Journal of Biochemistry & Cell Biology·Zeinab Y MotaweJerome W Breslin
Aug 21, 2018·Neurochemistry International·Michael J TomlinsonRoxanne A Vaughan
May 29, 2021·RSC Medicinal Chemistry·Hebaalla Agha, Christopher R McCurdy
Jun 3, 2021·International Journal of Molecular Sciences·Mikhail V VoroninSergei B Seredenin
Jun 2, 2021·Alcoholism, Clinical and Experimental Research·Sema G QuadirValentina Sabino
Jul 27, 2021·Frontiers in Physiology·Richa AishwaryaMd Shenuarin Bhuiyan
Apr 3, 2019·Journal of Medicinal Chemistry·Elisabeth KronenbergBernhard Wünsch
Oct 24, 2020·Journal of Medicinal Chemistry·Giuseppe Felice MangiatordiMarialessandra Contino

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Related Papers

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Takato HiranitaJonathan L Katz
The Journal of Pharmacology and Experimental Therapeutics
Jonathan L KatzChristopher R McCurdy
Proceedings of the National Academy of Sciences of the United States of America
Daniela MarazzitiGlauco P Tocchini-Valentini
© 2022 Meta ULC. All rights reserved