PMID: 8582787Sep 1, 1995Paper

The sigma ligand SR 31747 prevents the development of acute graft-versus-host disease in mice by blocking IFN-gamma and GM-CSF mRNA expression

International Journal of Immunopharmacology
P CarayonP Casellas

Abstract

SR 31747 is a sigma ligand which prevents the development of acute graft-versus-host reaction (GvHR) in hybrid B6D2F1 mice injected with C57BL/6 parental spleen cells. In the present study, we showed that this drug dramatically impaired the GvHR-associated increase in the numbers of both B-lymphocytes and polymorphonuclear cells (PMNs) in the spleen. Because SR 31747 blocked the GvHR-induced expression of both interleukin-2 and transferrin receptors on T-lymphocytes, it is very likely that this molecule prevented the disease through an inhibition of T-lymphocyte activation. Cytokine messenger RNA analyses on spleen cells revealed that SR 31747 blocked IFN-gamma and GM-CSF but not IL-4 transcription. These effects, which are different from those observed with either cyclosporin-A or dexamethasone, strongly suggest that SR 31747 preferentially inhibits the Th1 lymphocyte subset.

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Citations

Jan 27, 2004·Journal of Neuroimmunology·Brian GardnerSherven Sharma
Jun 10, 2015·Journal of Receptor and Signal Transduction Research·Colin G Rousseaux, Stephanie F Greene
Jan 1, 1997·Hematology·G R HillJ L Ferrara
Jan 8, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Fabrizio MontecuccoSabine Steffens
Jul 7, 2005·Pathology Oncology Research : POR·Peter SimsaBeatrix Kotlan
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li X ZhuSteven M Dubinett
Oct 28, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Nis Pedersen JørgensenPer Borghammer
Dec 18, 2020·Pharmacological Reviews·Antonio InserraGabriella Gobbi
May 1, 1996·Journal of Pharmaceutical and Biomedical Analysis·D DussossoyP Casellas

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