PMID: 9159399May 1, 1997Paper

The sigma(E) and the Cpx signal transduction systems control the synthesis of periplasmic protein-folding enzymes in Escherichia coli

Genes & Development
P N Danese, Thomas J Silhavy

Abstract

In Escherichia coli, the heat shock-inducible sigma-factor sigma(E) and the Cpx two-component signal transduction system are both attuned to extracytoplasmic stimuli. For example, sigma(E) activity rises in response to the overproduction of various outer-membrane proteins. Similarly, the activity of the Cpx signal transduction pathway, which consists of an inner-membrane sensor (CpxA) and a cognate response regulator (CpxR), is stimulated by overproduction of the outer-membrane lipoprotein, NlpE. In response to these extracytoplasmic stimuli, sigma(E) and CpxA/CpxR stimulate the transcription of degP, which encodes a periplasmic protease. This suggests that CpxA/CpxR and sigma(E) both mediate protein turnover within the bacterial envelope. Here, we show that CpxA/CpxR and sigma(E) also control the synthesis of periplasmic enzymes that can facilitate protein-folding reactions. Specifically, sigma(E) controls transcription of fkpA, which specifies a periplasmic peptidyl-prolyl cis/trans isomerase. Similarly, the Cpx system controls transcription of the dsbA locus, which encodes a periplasmic enzyme required for efficient disulfide bond formation in several extracytoplasmic proteins. Taken together, these results indicate that sig...Continue Reading

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Citations

Jan 21, 2003·Mass Spectrometry Reviews·Ran Rosen, Eliora Z Ron
Apr 2, 2005·Current Opinion in Microbiology·Natividad Ruiz, Thomas J Silhavy
Apr 10, 2013·Research in Microbiology·Séverine CollinAnthony P Pugsley
Oct 16, 2003·Progress in Lipid Research·Koji Mikami, Norio Murata
Jan 30, 2002·FEMS Microbiology Letters·M GoeckeN L Martin
Oct 14, 2003·FEMS Microbiology Letters·Gerhard HeusippVirginia L Miller
Sep 14, 1999·FEMS Microbiology Letters·C DorelP Lejeune
Mar 6, 1999·Current Opinion in Microbiology·D G ThanassiS J Hultgren
Feb 19, 2000·Current Opinion in Microbiology·F G SauerS J Hultgren
May 14, 1999·Current Opinion in Microbiology·T Yura, K Nakahigashi
May 14, 1999·Current Opinion in Microbiology·T L Raivio, T J Silhavy
May 23, 2006·Nature Reviews. Microbiology·Gary RowleyMark Roberts
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rachel J DuttonDana Boyd
Dec 15, 2010·The Journal of Biological Chemistry·Stephanie HelbigVolkmar Braun
Jan 22, 2011·Antioxidants & Redox Signaling·Guoping Ren, James C A Bardwell
Oct 3, 2007·Genes & Development·Joseph G SklarThomas J Silhavy
Oct 24, 2007·Applied and Environmental Microbiology·Erin E HerbertHeidi Goodrich-Blair
Mar 10, 2004·Applied and Environmental Microbiology·Eva H HansenLone Gram
May 23, 2007·Infection and Immunity·Katrin E CarlssonMatthew S Francis
Jul 11, 2007·Infection and Immunity·Katrin E CarlssonMatthew S Francis
Jun 23, 2009·Journal of Bacteriology·Leyla Slamti, Matthew K Waldor

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