The signal metabolite trehalose-6-phosphate inhibits the sucrolytic activity of sucrose synthase from developing castor beans

FEBS Letters
Eric T FedosejevsWilliam C Plaxton

Abstract

In plants, trehalose 6-phosphate (T6P) is a key signaling metabolite that functions as both a signal and negative feedback regulator of sucrose levels. The mode of action by which T6P senses and regulates sucrose is not fully understood. Here, we demonstrate that the sucrolytic activity of RcSUS1, the dominant sucrose synthase isozyme expressed in developing castor beans, is allosterically inhibited by T6P. The feedback inhibition of SUS by T6P may contribute to the control of sink strength and sucrolytic flux in heterotrophic plant tissues.

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Citations

Feb 11, 2020·Frontiers in Plant Science·Tran Le Cong Huyen Bao PhanPatrick Van Dijck
Feb 26, 2019·Frontiers in Plant Science·Ofer Stein, David Granot
Apr 2, 2020·BMC Genomics·Michelle Orane SchembergerRicardo Antonio Ayub
Aug 28, 2021·International Journal of Molecular Sciences·Bianyun YuDengjin Bing

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