PMID: 9525252Apr 3, 1998Paper

The signal model: a possible explanation for the conversion of DNA double-strand breaks into chromatid breaks

International Journal of Radiation Biology
P E Bryant

Abstract

To present and evaluate the 'signal' model for the formation of radiation-induced chromatid breaks. Chromatid breaks in human cells represent the apparent interstitial loss of up to about 40 Mbp of DNA, difficult to account for as single lesions under the classical 'breakage-and-reunion' hypothesis. If breakage-first resulted from two interacting DNA double-strand breaks (dsb) with the loss or displacement of the intervening fragment, a dose-squared relationship would be predicted for chromatid breaks. However, the relationship between chromatid break frequency and dose for human cells is linear. The alternative 'exchange' model of Revell is based on the principle of the interaction of two initiating lesions, thus also predicting a dose-squared relationship for chromatid 'breaks'. The signal model explains the conversion of dsb into chromatid breaks on the assumption that a single dsb generates a signal which triggers the cell to initiate a recombinational exchange involving a large loop of chromatin. Incomplete exchanges would be observed as chromatid breaks. Possible candidates for the signalling molecule(s) are DNA protein kinase (DNA PK) and the ATM protein.

Citations

Sep 8, 2011·Journal of Assisted Reproduction and Genetics·Sahar Moghbeli-NejadParvin Fallahi
Oct 2, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Hossein Mozdarani, Elmina Nazari
Feb 12, 2009·International Journal of Radiation Biology·M S Sasaki
Aug 4, 2005·International Journal of Radiation Biology·O L HoweC Mothersill
Mar 30, 2010·Mutation Research·Peter E BryantSamantha Y A Terry
Sep 29, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H Peter RodemannEkkehard Dikomey
Sep 29, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter E Bryant
Aug 10, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M DigweedK Sperling
Jul 31, 2008·British Journal of Cancer·S Y A TerryP E Bryant
Jan 23, 2003·Radiation Research·Peter E BryantDieter Frankenberg
May 6, 2003·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·K H ChadwickM J P Brugmans
Apr 1, 2005·International Journal of Radiation Biology·Helen B Forrester, Ian R Radford
Jun 20, 2017·Molecular Medicine Reports·Aleksandra M GorniewskaAneta Bialkowska
Sep 5, 1998·Mutation Research·P E Bryant
Jul 11, 2002·Mutation Research·G ObeM E Drets
Oct 26, 2001·Seminars in Radiation Oncology·K S LeskovD A Boothman
Dec 5, 2002·Mutation Research·John R K Savage

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