The signaling mechanism of ambient pH sensing and adaptation in yeast and fungi

The FEBS Journal
Tatsuya Maeda

Abstract

The four protein complexes termed endosomal sorting complexes required for transport (ESCRT) are key mediators of multivesicular body sorting/formation, retroviral budding and cell abscission, which share a membrane deformation process with the same topological change: vesicles budding away from the cytoplasm. Independent studies of the signal transduction pathways that mediate ambient pH sensing and adaptation in yeast and fungi revealed that these pathways share a conserved signaling mechanism that utilizes ESCRT complexes for its activation. This pathway in Saccharomyces cerevisiae, termed the Rim101 pathway, consists of both a sensing complex, which senses ambient alkaline pH, and a proteolytic complex, which proteolyzes and thereby activates the key transcription factor Rim101. Since the proteolytic complex is thought to be formed and activated on a platform of a multimerized ESCRT-III component Snf7, the organization, regulation and function of this pathway are dependent on the function of ESCRT complexes.

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Citations

Jul 10, 2013·The Journal of Cell Biology·Alexandre Toulmay, William A Prinz
Mar 13, 2012·The FEBS Journal·Masatoshi MakiHideki Shibata
Dec 9, 2014·Cell Cycle·Vincent R RichardVladimir I Titorenko
Nov 20, 2015·Current Genetics·Han Du, Guanghua Huang
Aug 30, 2016·International Journal of Molecular Sciences·Masatoshi MakiHideki Shibata
Nov 12, 2016·Nature Reviews. Drug Discovery·Yasuko OnoHiroyuki Sorimachi
Dec 13, 2017·Cell Death and Differentiation·Patrick RockenfellerFrank Madeo
Sep 6, 2015·Eukaryotic Cell·Yuan SunGuanghua Huang
Dec 15, 2018·ELife·Fernando Meza GutierrezDavid P Toczyski
Sep 11, 2019·FEMS Microbiology Reviews·Alexandros AthanasopoulosChristos Gournas
Apr 11, 2018·Oxidative Medicine and Cellular Longevity·Karamat MohammadVladimir I Titorenko
May 3, 2018·FEMS Yeast Research·Patrick Rockenfeller, Campbell W Gourlay
Mar 5, 2021·The Journal of Biological Chemistry·Natalie M GarzaVishal M Gohil

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