The Signaling Pathways Involved in the Antiatherosclerotic Effects Produced by Chinese Herbal Medicines

BioMed Research International
Li LuXiaomei Guo

Abstract

Cardiovascular diseases (CVDs) are considered to be the predominant cause of death in the world. Chinese herb medicines (CHMs) have been widely used for the treatment of CVDs in Asian countries for thousands of years. One reason of high efficacy of CHMs in treating CVDs is attributed to their inhibition in atherosclerosis (AS) development, a critical contributor to CVDs occurrence. Cumulative studies have demonstrated that CHMs alleviate atherogenesis via mediating pathophysiologic events involved in AS. However, there is deficiency in the summaries regarding antiatherogenic signal pathways regulated by CHMs. In this review, we focus on the signal cascades by which herb medicines and relevant extractives, derivatives, and patents improve proatherogenic processes including endothelium dysfunction, lipid accumulation, and inflammation. We mainly elaborate the CHMs-mediated signaling pathways in endothelial cells, macrophages, and vascular smooth muscle cells of each pathogenic event. Moreover, we briefly describe the other AS-related factors such as thrombosis, autophagy, immune response, and noncoding RNAs and effects of CHMs on them in the way of cascade regulation, which is helpful to further illustrate the molecular mechanism...Continue Reading

References

Aug 9, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wan-Jung LuJoen-Rong Sheu
Oct 21, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Brandi N Davis-DusenberyAkiko Hata
Nov 9, 2011·Nature Medicine·Christian Weber, Heidi Noels
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xinni XieYonggong Zhai
Mar 24, 2012·The Journal of Pharmacology and Experimental Therapeutics·Yeonsoo JoeHun Taeg Chung
Jun 9, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Suowen XuPeiqing Liu
Oct 23, 2012·International Immunopharmacology·Irina Tsoy NizamutdinovaHye Jung Kim
Dec 12, 2012·The American Journal of Chinese Medicine·Paul ChanHong-Jye Hong

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Citations

May 2, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shasha ZhengZhuyuan Fang

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