The signature of positive selection at randomly chosen loci.

Genetics
Molly Przeworski

Abstract

In Drosophila and humans, there are accumulating examples of loci with a significant excess of high-frequency-derived alleles or high levels of linkage disequilibrium, relative to a neutral model of a random-mating population of constant size. These are features expected after a recent selective sweep. Their prevalence suggests that positive directional selection may be widespread in both species. However, as I show here, these features do not persist long after the sweep ends: The high-frequency alleles drift to fixation and no longer contribute to polymorphism, while linkage disequilibrium is broken down by recombination. As a result, loci chosen without independent evidence of recent selection are not expected to exhibit either of these features, even if they have been affected by numerous sweeps in their genealogical history. How then can we explain the patterns in the data? One possibility is population structure, with unequal sampling from different subpopulations. Alternatively, positive selection may not operate as is commonly modeled. In particular, the rate of fixation of advantageous mutations may have increased in the recent past.

References

Oct 1, 1992·Genetics·R R HudsonW P Maddison
Oct 1, 1991·Genetics·W H Li, L A Sadler
Dec 1, 1989·Genetics·N L KaplanC H Langley
Oct 1, 1974·Theoretical Population Biology·W H Li, M Nei
Oct 1, 1995·Theoretical Population Biology·Y X Fu
May 13, 1999·Nature Genetics·M J RiederD A Nickerson
Jul 6, 2000·Genetics·J C Fay, C I Wu
Dec 5, 2000·Trends in Genetics : TIG·S P Otto
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·A TakahashiC I Wu
May 24, 2001·Molecular Biology and Evolution·J D Wall, R R Hudson
May 31, 2001·Genome Research·R Martínez-AriasJ Bertranpetit
Jun 19, 2001·American Journal of Human Genetics·J K Pritchard, M Przeworski
Aug 30, 2001·Trends in Genetics : TIG·M W Nachman
Oct 19, 2001·Genetics·J Wakeley, N Aliacar
Oct 30, 2001·Current Opinion in Genetics & Development·P Andolfatto
Oct 30, 2001·Current Opinion in Genetics & Development·J C Fay, C I Wu
Dec 26, 2001·American Journal of Human Genetics·Martha T HamblinAnna Di Rienzo
Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoav GiladKarl Skorecki
Mar 1, 1951·Annals of Eugenics·S WRIGHT

❮ Previous
Next ❯

Citations

Aug 21, 2008·Nature Reviews. Genetics·Elinor K Karlsson, Kerstin Lindblad-Toh
Sep 20, 2008·PLoS Genetics·Jeffrey D JensenPeter Andolfatto
May 29, 2004·Genetics·Hannah SundströmHans Ellegren
May 7, 2021·Genetics·Alexandre M Harris, Michael DeGiorgio
Oct 10, 2006·Genetics·Doris Bachtrog, Peter Andolfatto
Oct 24, 2008·PLoS Biology·Josefa GonzálezDmitri A Petrov
Oct 17, 2006·PLoS Genetics·Haipeng Li, Wolfgang Stephan
Jan 3, 2006·Genetics·Floyd A Reed, Sarah A Tishkoff
May 9, 2021·Molecular Ecology Resources·Hirzi LuqmanDaniel Wegmann
Jun 26, 2008·European Journal of Human Genetics : EJHG·Fulvio CrucianiRosaria Scozzari
Aug 28, 2002·Genetics·Christopher Toomajian, Martin Kreitman
Dec 17, 2011·Genetics·Kosuke M Teshima, Hideki Innan
Apr 5, 2005·American Journal of Human Genetics·C Geoffrey WoodsWolfgang Enard
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hideki Innan, Yuseob Kim
May 14, 2020·Genetics·Matthew M Osmond, Graham Coop
Jul 29, 2004·Genetics·Yuseob Kim, Rasmus Nielsen
Jun 21, 2012·Genetics·Graham Coop, Peter Ralph
Aug 11, 2004·Theoretical Population Biology·Richard Durrett, Jason Schweinsberg
Dec 22, 2006·Genetics·P PfaffelhuberA Wakolbinger
May 25, 2005·Genetics·Jeffrey D JensenCarlos D Bustamante
Oct 26, 2007·Trends in Genetics : TIG·Jeffrey D JensenCharles F Aquadro
Sep 21, 2002·Genetics·Jeffrey D WallMolly Przeworski
Jan 1, 2013·G3 : Genes - Genomes - Genetics·Rob W NessPeter D Keightley
Jan 24, 2007·Genetics·John P Huelsenbeck, Peter Andolfatto
Oct 1, 2007·Expert Opinion on Drug Discovery·Roger K Prichard
Sep 24, 2004·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·J A WilderH Hollocher
Apr 19, 2006·Current Biology : CB·Philipp KhaitovichSvante Pääbo
Jul 1, 2005·The Journal of Biological Chemistry·Holger RömplerTorsten Schöneberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.