Abstract
Cow's milk allergy (CMA) is the most common food allergy in infancy. Food allergy is generally triggered through ingestion, but can also be triggered through skin contact. We investigated the incidence and the clinical significance of cow's milk protein (CMP)-induced contact urticaria in individuals with CMA with and without atopic dermatitis (AD). A total of 157 children of whom 133 were diagnosed with CMA were participated. The study was based on observational data gathered in the course of patient care, including a skin prick test and a 'finger test', in which cow's milk is applied on the cheek by a physician's finger to detect contact urticaria. Eighty nine of 133 patients (66.9%) had IgE-mediated CMA. Forty of these 89 (44.9%) tested positive in the finger test. Family atopy was higher in those with positive contact urticaria [21/40 (52.5%) vs. 14/49 (28.5%), p = 0.029]. Patients with positive vs. negative CMP contact urticaria had higher incidence of multiple food allergies [20 of 40 (50%) vs. 7/49 (14.3%), p < 0.004]. IgE-mediated CMA patients with AD had statistically higher CMP allergic contact urticaria compared to patients without AD [71% (15/21) vs. 37% (25/68), p = 0.0064]. Children with non-IgE milk allergy and he...Continue Reading
References
Sep 1, 1981·Journal of the American Academy of Dermatology·G von Krogh, H I Maibach
Nov 1, 1994·Contact Dermatitis·A P OranjeP H Dieges
Nov 24, 1998·Allergy·B Wüthrich
May 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·B M TanS L Bahna
Mar 22, 2002·Allergy·I DalalE Somekh
Aug 13, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ilan DalalRam Reifen
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Natalija NovakDonald Y M Leung
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Cezmi A AkdisUNKNOWN European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology
Jul 27, 2006·Allergy·C A AkdisUNKNOWN Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Group
Mar 10, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Adi CohenYitzhak Katz
Jun 15, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Y LevyY L Danon
Jun 23, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·G Du ToitG Lack
Jun 15, 2010·The Journal of Allergy and Clinical Immunology·Yitzhak KatzMoshe Leshno
Jun 22, 2011·Pediatrics·Ruchi S GuptaJane L Holl
Apr 3, 2012·The Journal of Allergy and Clinical Immunology·Gideon Lack
Jan 7, 2014·The Journal of Allergy and Clinical Immunology·Scott H Sicherer, Hugh A Sampson
Feb 26, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A Wesley Burks, Michael H Land
Nov 20, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Francesca CiprianiGiampaolo Ricci